Stroke Flashcards

1
Q

What is a stroke?

A

A stroke occurs when blood flow to a part of the brain is interrupted or reduced, preventing brain tissue from receiving oxygen and nutrients, leading to cell death.

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2
Q

What are the two main types of stroke?

A

Ischemic stroke (caused by a blockage) and hemorrhagic stroke (caused by bleeding).

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3
Q

What is an ischemic stroke?

A

It occurs when a blood clot blocks or narrows an artery leading to the brain, reducing blood flow.

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4
Q

What is a hemorrhagic stroke?

A

It occurs when a blood vessel in the brain ruptures, causing bleeding within or around the brain.

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5
Q

What is a transient ischemic attack (TIA)?

A

A TIA, or “mini-stroke,” is a temporary blockage of blood flow to the brain, usually resolving within minutes to hours without permanent damage.

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6
Q

What are the common risk factors for stroke?

A

Hypertension, diabetes, smoking, high cholesterol, atrial fibrillation, and a sedentary lifestyle.

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7
Q

What are the FAST signs of stroke?

A

F = Face drooping, A = Arm weakness, S = Speech difficulty, T = Time to call emergency services.

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8
Q

What causes ischemic strokes?

A

Atherosclerosis, blood clots, embolisms, and narrowing of the blood vessels in the brain.

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9
Q

What causes hemorrhagic strokes?

A

High blood pressure, aneurysms, arteriovenous malformations (AVMs), and head trauma.

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10
Q

What is the role of atrial fibrillation in stroke?

A

Atrial fibrillation can lead to the formation of blood clots in the heart, which can travel to the brain and cause an ischemic stroke.

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11
Q

What imaging modality is most commonly used to diagnose a stroke?

A

Non-contrast CT scan, followed by MRI if necessary, to determine stroke type and extent.

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12
Q

How is an ischemic stroke treated in the acute phase?

A

Intravenous thrombolysis with tissue plasminogen activator (tPA) if within 4.5 hours of symptom onset, or mechanical thrombectomy.

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13
Q

What is tPA, and when is it used?

A

Tissue plasminogen activator (tPA) is a clot-busting drug used to treat ischemic strokes within 4.5 hours of symptom onset.

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14
Q

What is the role of aspirin in stroke management?

A

Aspirin is used in the secondary prevention of ischemic strokes by reducing the risk of clot formation.

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15
Q

How is a hemorrhagic stroke managed acutely?

A

Controlling blood pressure, reversing anticoagulation, and in some cases, surgical intervention to relieve pressure or repair the vessel.

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16
Q

What is a subarachnoid hemorrhage?

A

Bleeding in the space between the brain and the thin tissues covering it, often due to a ruptured aneurysm.

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16
Q

What are lacunar strokes?

A

Small ischemic strokes that occur in the deep structures of the brain, typically due to small vessel disease.

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17
Q

What is the penumbra in stroke pathology?

A

The area of brain tissue around the infarct that is at risk but still salvageable if blood flow is restored quickly.

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17
Q

What are the complications of stroke?

A

Paralysis, difficulty speaking, swallowing issues, cognitive deficits, and risk of recurrent strokes.

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18
Q

What is a cerebral aneurysm?

A

A weak spot in a brain artery that balloons and can potentially rupture, leading to a hemorrhagic stroke.

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19
Q

What is carotid artery stenosis, and how does it relate to stroke?

A

Narrowing of the carotid arteries can reduce blood flow to the brain and increase the risk of ischemic stroke.

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19
Q

What is the role of antiplatelet therapy in stroke prevention?

A

Medications like aspirin and clopidogrel are used to reduce the risk of future ischemic strokes by preventing clot formation.

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20
Q

What is the NIH Stroke Scale (NIHSS)?

A

A systematic assessment tool used to quantify the severity of a stroke and guide treatment decisions.

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21
Q

What is the main long-term goal of stroke rehabilitation?

A

To maximize recovery of function and improve quality of life through physical, occupational, and speech therapy.

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21
Q

How is stroke-related dysphagia managed?

A

By conducting a swallowing assessment and modifying diet texture, with potential use of feeding tubes if necessary.

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21
Q

What is the most common long-term deficit after a stroke?

A

Hemiparesis, or weakness on one side of the body.

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22
Q

What is the relationship between hypertension and stroke risk?

A

Chronic high blood pressure is the leading modifiable risk factor for both ischemic and hemorrhagic strokes.

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23
Q

What is an embolic stroke?

A

A type of ischemic stroke where a clot forms elsewhere in the body (e.g., heart) and travels to the brain.

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24
Q

How does diabetes contribute to stroke risk?

A

Diabetes accelerates atherosclerosis, increasing the risk of ischemic stroke through blood vessel damage.

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24
Q

How does atrial fibrillation increase stroke risk?

A

It causes irregular heartbeats, leading to blood pooling in the heart and clot formation, which can travel to the brain.

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24
Q

What is the importance of early mobilization after a stroke?

A

It helps reduce the risk of complications such as deep vein thrombosis, pneumonia, and improves recovery outcomes.

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25
Q

What are the signs of increased intracranial pressure in hemorrhagic stroke?

A

Headache, nausea, vomiting, decreased consciousness, and pupillary changes.

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25
Q

What is endarterectomy, and when is it used?

A

A surgical procedure to remove plaque from the carotid artery, used to prevent strokes in patients with significant stenosis.

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25
Q

What role do statins play in stroke prevention?

A

Statins reduce cholesterol levels and have anti-inflammatory effects, decreasing the risk of ischemic strokes.

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26
Q

What is reperfusion therapy in ischemic stroke?

A

Treatments aimed at restoring blood flow, including tPA administration and mechanical thrombectomy.

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26
Q

What are common symptoms of a brainstem stroke?

A

Double vision, dizziness, imbalance, difficulty swallowing, and sometimes “locked-in syndrome.”

26
Q

What is the time window for administering tPA in ischemic stroke?

A

Ideally within 4.5 hours of symptom onset.

26
Q

What is cerebral edema, and how is it managed after stroke?

A

Swelling of the brain tissue, managed with medications like mannitol, hypertonic saline, or decompressive surgery.

27
Q

What are the potential complications of tPA therapy?

A

Intracranial bleeding and systemic hemorrhage.

27
Q

What are the types of motor deficits commonly seen after a stroke?

A

Hemiplegia (paralysis of one side of the body) or hemiparesis (weakness on one side).

28
Q

What are the main cognitive deficits that can occur after a stroke?

A

Memory problems, attention deficits, and difficulty with problem-solving and executive functions.

29
Q

What is the significance of time in stroke treatment?

A

“Time is brain” — the quicker treatment is administered, the better the outcome and the less brain tissue damage.

30
Q

How is hypertension managed after a stroke?

A

Blood pressure is carefully lowered to reduce the risk of further strokes while avoiding rapid reductions that can harm brain perfusion.

31
Q

What is “ischemia”?

A

Reduced blood flow to tissue, leading to a lack of oxygen and nutrients, which can result in cell damage or death.

32
Q

What is “hemorrhage”?

A

Bleeding, typically caused by the rupture of a blood vessel, leading to blood accumulation in or around the brain.

33
Q

What is “infarction”?

A

Death of tissue due to prolonged lack of blood supply, as seen in ischemic stroke.

34
Q

What is “atherosclerosis”?

A

A disease process where plaque builds up in the arteries, leading to narrowing and an increased risk of stroke.

34
Q

What is a “lacunar stroke”?

A

A small, deep ischemic stroke in the brain’s subcortical structures, often caused by small vessel disease.

35
Q

What is a “thrombus”?

A

A blood clot that forms within a blood vessel, potentially causing an ischemic stroke if it blocks blood flow to the brain.

36
Q

What is an “embolus”?

A

A blood clot or other debris that forms elsewhere in the body and travels through the bloodstream to the brain, causing a stroke.

37
Q

What is “penumbra”?

A

The area of brain tissue surrounding the core of an infarct that is at risk but still viable if treated quickly.

38
Q

What is “necrosis” in the context of stroke?

A

Death of brain cells caused by prolonged lack of oxygen due to disrupted blood supply.

39
Q

What is “transient ischemic attack (TIA)”?

A

A temporary blockage of blood flow to the brain, causing stroke-like symptoms that resolve within 24 hours.

40
Q

What is a “cerebral aneurysm”?

A

A weakened or ballooned area in the wall of an artery in the brain, which can rupture and cause a hemorrhagic stroke.

41
Q

What is “arteriovenous malformation (AVM)”?

A

A congenital tangle of blood vessels in the brain that can rupture and cause hemorrhagic stroke.

42
Q

What is “intracerebral hemorrhage (ICH)”?

A

Bleeding within the brain tissue itself, usually caused by high blood pressure or trauma.

43
Q

What is “subarachnoid hemorrhage (SAH)”?

A

Bleeding into the space between the brain and the thin tissues covering it, often due to a ruptured aneurysm.

44
Q

What is “cerebral edema”?

A

Swelling of brain tissue due to accumulation of fluid, commonly occurring after a stroke.

45
Q

What is “mechanical thrombectomy”?

A

A procedure to physically remove a blood clot from an artery in the brain, used in some ischemic stroke cases.

45
Q

What is “tPA (tissue plasminogen activator)”?

A

A clot-busting drug used to treat ischemic stroke by dissolving the clot and restoring blood flow.

46
Q

What is “thrombolysis”?

A

The medical breakdown of blood clots, often with drugs like tPA, used to treat ischemic strokes.

47
Q

What is “carotid endarterectomy”?

A

A surgical procedure to remove plaque from the carotid artery to prevent strokes caused by carotid artery stenosis.

48
Q

What is “carotid artery stenosis”?

A

Narrowing of the carotid arteries, which supply blood to the brain, increasing the risk of stroke.

49
Q

What is “hyperlipidemia” in stroke risk?

A

Elevated levels of lipids (fats) in the blood, which contribute to atherosclerosis and increase the risk of stroke.

50
Q

What is “hemiplegia”?

A

Paralysis of one side of the body due to stroke.

51
Q

What is “intravenous thrombolysis”?

A

Administration of drugs like tPA through the vein to dissolve clots during an ischemic stroke.

52
Q

What is “aphasia”?

A

A communication disorder caused by damage to the brain’s language centers, common after a stroke.

53
Q

What is “hemiparesis”?

A

Weakness on one side of the body, often a consequence of stroke.

54
Q

What is “dysarthria”?

A

A motor speech disorder caused by stroke, leading to difficulty with articulation and speech clarity.

55
Q

What is “neglect syndrome”?

A

A condition in which a stroke patient ignores or is unaware of one side of their body, often the side affected by stroke.

56
Q

What is “homonymous hemianopia”?

A

A visual field defect where a person loses half of the visual field in both eyes on the same side, often due to stroke.

57
Q

What is “silent stroke”?

A

A stroke that does not cause noticeable symptoms but can still cause brain damage, detected on brain imaging.

57
Q

What is “brain herniation”?

A

A serious condition where brain tissue shifts due to pressure after a stroke, potentially leading to death.

58
Q

What is “neuroplasticity”?

A

The brain’s ability to reorganize and form new neural connections, critical in stroke recovery.

58
Q

What is “blood-brain barrier disruption” in stroke?

A

Damage to the protective barrier around the brain during stroke, allowing harmful substances to enter brain tissue.

59
Q

What is “vasospasm” in the context of stroke?

A

Narrowing of blood vessels following a subarachnoid hemorrhage, reducing blood flow to brain tissue.

59
Q

What is “paradoxical embolism”?

A

A blood clot from the venous system that crosses to the arterial system (e.g., through a patent foramen ovale) and can cause a stroke.

60
Q

What is “TIA mimic”?

A

Conditions like migraine, seizures, or hypoglycemia that can mimic the symptoms of a transient ischemic attack.

61
Q

What is “glutamate excitotoxicity”?

A

Excessive release of glutamate during stroke, leading to neuronal injury and cell death.

62
Q

What is “post-stroke spasticity”?

A

Increased muscle tone and stiffness following a stroke, making movement difficult.

63
Q

What is “cerebral autoregulation”?

A

The brain’s ability to maintain stable blood flow despite changes in systemic blood pressure, often disrupted in stroke.

64
Q

What is “watershed stroke”?

A

A type of stroke that occurs in the border zones between major cerebral arteries, often due to low blood flow.

65
Q

What is “phagocytosis” in stroke recovery?

A

The process by which immune cells remove dead brain cells and debris after a stroke.

66
Q

What is “angiogenesis”?

A

Formation of new blood vessels in the brain during the recovery phase after a stroke.

67
Q

What is “reperfusion injury”?

A

Damage caused when blood flow is restored to brain tissue after ischemia, due to inflammation and oxidative stress.

68
Q

What is “autonomic dysfunction” after stroke?

A

Abnormal function of the autonomic nervous system, which can affect heart rate, blood pressure, and digestion.

68
Q

What is “brainstem stroke”?

A

A stroke affecting the brainstem, which can impact vital functions such as breathing, heart rate, and consciousness.

69
Q

What is “endovascular therapy”?

A

A minimally invasive treatment for stroke, often involving the removal of clots through a catheter inserted into blood vessels.