Stroke Flashcards

1
Q

Stroke : Blood supply of brain - Internal carotid artery

A

Internal carotid artery - gives off two branches
1 . Middle cerebral artery which supplies
Lateral portion of;
* Frontal lobe
* Temporal lobe
* Parital lobe

2 . Anterior cerebral artery which supplies
Medial portion of
* Frontal lobe
* Parietal lobe

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2
Q

Stroke : Blood supply of brain - Vertebral artery

A

Vertebral artery branches to form;
1 . Basilar artery
supplying the
* Cerebellum
* Brainstem

2 . Basilar artery branches off to give : L+R Posterior cerebral arteries
which supply the;
* Occipital lobe
* Temporal lobe
* Thalamus

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3
Q

Stroke : Middle cerebral artery stroke

A

Middle cerebral artery - branch of the Internal carotid supplies;

1 . Lateral Frontal lobe
-Pre-central gyrus controlling voluntary muscle movements of the upper limb and facial motor movement
-Contains Broca’s area - Speech production
* Contralateral hemiparesis of Upper limbs
* Facial droop
* Aphasia

2 . Lateral Parietal lobe
-Post central gyrus responsible for sensation
* Contralateral upper limp sensory dysfunction

3 . Lateral Temporal lobe
-Wernicke’s area : language comprehension
* Difficulty in language comprehension

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4
Q

Anterior cerebral artery : Anatomy of blood supply

A

1 . Medial Frontal lobe
Controls lower limb movement and executive functioning

2 . Medial Parital lobe
Controls lower limb sensation

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5
Q

Stroke : Anterior cerebral artery stroke

A

1 . Medial Frontal lobe
Controls lower limb movement and executive functioning
* Contralateral lower limb weakness
* Cognitive and behavioral changes

2 . Medial Parital lobe
Controls lower limb sensation
* Contralateral lower limb sensory dysfunction

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6
Q

Stroke : Posterior cerebral artery blood supply

A

Branch of the Basilar artery which stems from the vertebral artery supplies

1 . Occipital lobe - Visual cortex

2 . Thalamus - Relays motor and sensory signals to the cerebral cortex.

3 . Temporal lobe - Hippocampus, language processing area

4 . Midbrain - region of the brainstem, relays centre for visual, auditory and motor pathways
* Contains oculomotor/Trochlear nuclei and modulates eye movement

  • Reticular activating system : controls wakefulness and alertness
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7
Q

Stroke : Posterior cerebral artery stroke

A

Branch of the Basilar artery which stems from the vertebral artery supplies

1 . Occipital lobe - Visual cortex
* Homonymous Hemianopia and Cortical Blindness

2 . Thalamus - Relays motor and sensory signals to the cerebral cortex.

3 . Temporal lobe - Hippocampus, language processing area
* Speech and language disturbance - difficulty finding words, speech comprehension difficulties

4 . Midbrain - region of the brainstem, relays centre for visual, auditory and motor pathways
-Contains oculomotor/Trochlear nuclei and modulates eye movement
* Diplopia and Eye movement abnormalities

-Reticular activating system : controls wakefulness and alertness
* Altered levels of consciousness

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8
Q

Stroke : Cerebellar artery stroke

A

Posterior inferior cerebellar artery stroke
* Anatomy : Branch of the vertebral artery, supplies inferior, posterior and lateral aspect of the cerebellum
Cerebellum : contains

  1. Lateral hemisphere : Movement coordination, balance and fine tuning motor controls
    -> Ataxia and loss of coordination, difficulties with gait, posture and fine motor tasks
  • Coordination of speech and articulation
    -> Dysarthria

2 . Trigeminal nucleus : Facial sensation and swallowing
-> Ipsilateral facial pain

Anterior inferior cerebellar artery stroke
* Same as above but also supplies;
1. Cochlear nucleus - hearing
-> Sudden sensorineural hearing loss
3. Vestibular nucleus — maintaining balance and coordinating eye movement
-> Vertigo with N+V
-> Nystagmus

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9
Q

Stroke : Cerebellar artery blood supply

A

Posterior inferior cerebellar artery stroke
* Anatomy : Branch of the vertebral artery, supplies inferior, posterior and lateral aspect of the cerebellum
Cerebellum : contains
1. Lateral hemisphere : Movement coordination, balance and fine tuning motor controls

  • Coordination of speech and articulation

2 .** Trigeminal nucleus : Facial sensation and swallowing**

Anterior inferior cerebellar artery
* Same as above but also supplies;
1. Cochlear nucleus - hearing

  1. Vestibular nucleus — maintaining balance and coordinating eye movement
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10
Q

Stroke : Lacunar stroke

A

1 . Internal capsule :
-Facilitates communication between the cerebral Cortex and the Spinal Chord
-Contains ascending and descending motor and sensory fibres
* Pure motor stroke : Sudden weakness affecting one side of the body
* Ataxic hemiparesis : Weakness or lack of coordination on one side of the body

2 . Thalamus : relay station for sensory information.
-Direct sensory input to cortical areas for further processing
* Pure sensory stroke : Sudden onset sensory deficit affecting one side of the body

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11
Q

Stroke : definition

A

Cerebrovascular accidentsare either:
* Ischaemic stroke : Ischaemiaorinfarctionof the brain tissue secondary to a disrupted blood supply
* Haemorrhagic stroke : Intracranial haemorrhage, with bleeding in or around the brain

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12
Q

Stroke : Assessment

A

ROSIER SCORE
* Exclude hyperglycaemia

Stroke likely if >0
New, acute onset of: (+ 1 point for each )
1. asymmetric facial weakness
2. asymmetric arm weakness
3. asymmetric leg weakness
4. speech disturbance
5. visual field defect

Lose 1 point for;
1. Loss of consciousness or syncope
2. Seizure activity

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13
Q

Stroke : Investigation

A
  1. Contrast CT scan
    * Differentiate between Haemorrhagic vs Ischaemic stroke
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14
Q

Ischaemic Stroke : Acute management

A
  1. Thrombolysis with alteplase
    Indic : < 4.5 hours of onset
  2. Thrombectomy
    Indication : Prefunctional status (<3 in Rankin scale, >5 NIHSS)
  3. Carotid Endartectomy
    Indication :
    * Acute troke
    * TIA in carotid territory
    * Carotid stenosis >70% or symptomatic
    * NOT severely disabled
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15
Q

Acute Ischaemic stroke : PACS mx

Posterior anterior circulation stroke

A
  1. Posterior anterior circulation stroke
    {Confirmed on CT/MRI scan
    * < 4.5 hour onset : Thrombectomy + Thrombolysis
    * < 6 hour onset : Thrombectomy
  • < 24 hours : Thrombectomy
    Indic : If potential to salvage brain tissue in limited infarct
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16
Q

Acute Ischaemic stroke : PPCA mx

A
  1. Proximal posterior circulation artery occlusion
    * Basilar/Posterior cerebral artery stroke

Mx
* < 4.5 hours : Thrombectomy + IV Thrombolysis
* < 24 hours : Thrombectomy
Indic : If potential to salvage brain tissue

17
Q

Acute Ischaemic stroke : Medical management

A

1. 300mg Aspirin
* Indic : Inschaemic stroke only

2. Avoid Tx Hypertension
unless Hypertensive emergency
* Low BP can worsen ischaemic

3. Longterm antiplatet therapy :
* Clopidogrel 75mg
* Second line : Aspirin + MR Dipyridamole
* Third line : Dipyridamole alone

4. Hold any anticoagulants
* Resumed 14 days after onset of stroke

5. Statin
* Cholesterol > 3.5
* 48 hours after stroke

18
Q
A