stress Flashcards
stress
the real or perceived threat to the homeostasis of an organism, that produces a stress response, which is a series of adaptive responses designed to protect the organism
stressor
The event triggering the stress response
stress response
the physiological response to the stressor
coping
Emotional, cognitive and/or behavioral response generated in response to a stress response
Homeostasis
the range of an organism’s ability, to regulate its environment so as to maintain a stable condition
Allostasis
The process of an organsim responding to a change in homeostasis
Allogenic Load
Challenges that cause an organism to begin and carry out efforts to maintain stability.
Acute stress
stress of immediate events that are a threat to survival or sense of wellbeing
Chronic stress
unique to humans in that we create stress from things that do not immediately affect our survival
Describe the stress bell-curve
Describe the 3 stages of stress
**immediate response **
- Sensory information gets interpreted cognitively via neocortex and affectively integrated via limbic system
- lasts 2 to 3 seconds
- neuromuscular nervous system detects stimuli and is activated
- parasymathetic activity activated
- increases heart rate, turns off digestion
intermediate response (adrenal response)
- epinepherine and norepineperine are released from the adrenal medulla (lasts 20-30 seconds)
**prolonged stress response **
- response to severe stress
- Hypothalamic-pituitary-adrenal axis (HPAC) activated
- prolonged stress responsible for disease
describe the hypothalmus-pituritary-adrenal axis
relate it to the prolonged stress response
- Hippocampus directs neural impulses to the hypothalamus to release corticotropin-releasing factor (CRF)
- CRF is sent to the anterior pituitary which releases adrenocorticotropic hormone (ACTH) and endorphines
- ATCH stimulates the release of glucocorticoids, cortisol and corticosterone which activate the long stress response
describe the effects of adrenal corticosteriods
- Decreases effects of insulin on blood glucose
- Increases breakdown of proteins
- Decreases inflammation, immune system function and healing
- Increased glucose production
- Increased urea production
- Increased release of free fatty acids
- Increased ketone body production
How does chronic stress affect the immune system?
Epinephrine and Norepinephrine
- alters circulation of leukocyte sub-populations
- decreases cytokine production and release
Glucocorticoids
- increses risk of infection by causing a shift in the type of T-helper cells the types of cytokines secreted
** cortisol secretion**
- responsible for more prolonged inhibition of cellular and humeral immune responses
define psychoneuroimmunology
Investigations of the bidirectional linkages between the CNS, the endocrine system and the immune system, and the clinical implications of these linkages.