Stress Flashcards
What is Stress?
Include study
Stress is “anything that throws your body out of homeostatic balance” (Sapolsky, 1994)
What are the sources of stressors?
Name 3
- Environmental (temp, noise)
- physiological(food quality, water deprivation)
- psychological (social subordination, novel situations)
Why does perceptions matter with stress?
Because what is stressful to one may be pleasurable to another
stress causes arousal that is considered averisive (uncomfortbale and disliked sensation) Kim and Diamond, 2002
What is the stress response?
- physiological and behavioural responses that help to reestablish homeostasis
- Upon perceiving a stressor, the hypothalamus signals neuronally to the adrenal medullae to secrete epinepherine (adrenaline) and norepinepherine(noradrenaline).
- Norepinephrine: continuously released into the blood stream,narrows blood vessels to increaseblood pressure
- Epinephrine: only released when stressed, itincreases heart rate and blood pressure, blood flow to the muscles and brain, and aids the conversion of glycogen
What is the result of epinephrine and norepinephrine being released?
they have stimulatory effectson the respiratory and cardiovascularsystems,increases blood flowto the muscles, and raises bloodglucose levels (“fight-or-flight-response”) -> readying the body for emergency/survival action
What does the hypothalamus release after epinephrine?
the hypothalamus releases CRH (Corticotropin-ReleasingHormone), which stimulates ACTH(AdrenoCorticoTropicHormone) release from the anterior pituitarygland. ACTH stimulatesglucocorticoidssecretion from the adrenalcortex.
What does CRH do?
CRH (Corticotropin-releasing-hormone) stimulates the release of ACTH (adrenoCortioTropic Hormone) from the pituitary glands
What does ACTH
ACTH(AdrenoCorticoTropicHormone) releases from the pituitarygland because of the release of CRH from the hypothalamus. ACTH stimulatesglucocorticoidssecretion from the adrenalcortex.
What is the HPA axis?
- Hypothalamus
- Pituitary
- Adrenal
- A stressor affects the body
- Hypothalamus sends a neuronal signal to adrneal gland which releases adrenaline and noradrenaline (this is immediate fight or flight)
- Then Hypothalamus releases CRH
- This stimulates Pituitary to release ACTH
- This causes the Adrenal gland to release glucocorticoids (Cortisol)
- Cortisol is always regulated by hypothalmus and pituitary so how much CRH and ACTH is released, meaning it as a negative feedbakc loop as its always going up and down
What are glucocorticoids ?
CORTISOL
What does cortisol do in relation to stress?
- shut down or alter functions that get in the way of the fight or flight response such as digestive or reproductive systems, immune of growth systems too.
- although cortisol is known as the stress hormone, it doesnt just promote the stress response. It also helps the body recover from stress and prepare for more potential stressors
What are the adaptive effects of the stress response?
Increased availability of energy
Increased oxygen intake
Decreased blood flow to organs not necessary for movement
Inhibition of processes not necessary for immediate survival, e.g. digestion, immune function, reproduction
Decreased pain perception
Enhanced sensory function and memory
Non-specific: exhibited by both predator and prey
What is general adpatation syndrome (GAS)?
Stage 1: alarm reaction
Stage 2: resistance
Stage 3: exhaustion/onset of stress pathology
e.g. Selye, 1950: rats in low temperature conditions for
2 days (stressresponse: immune suppression, atrophy of lymph nodes)
2 weeks (adaptation)
2 months (death)
What are some examples of the prolonged pathological effects of stress?
Fatigue
Inhibited growth and repair process of the body
Pepetic ulcers because of immune system supression
Loss of libido
Impaired disease resistance - can lead to cancer
What are the bodys immediate stress responses?
- inhibited digestion
- inhibited growth
- inhibited reproduction
- altered immune function and inflammatory repsonse
- enhanced cognition
What is the time point where short term effects of stress become long-term maladaptive effects ?
Exact time point is not known
Do glucocorticoids (cortisol) have:
A : Activational effects on brain and behaviour
B : Organisational effects on brian and behaviour
C : BOTH
C - BOTH !
Is glucocorticoid secretion under a negative or positive feedback loop and explain
NEGATIVE FEEDBACK LOOP
1. Hypothalamus releases CRH
2. CRH travels to pituitary, stimulating release of ACTH
3. ACTH stimulates adrenal gland to release glutocorticoids (cortisol)
4. As cortisol rises, this exerts negative feedback on the hypothalamus and pituitary glands, signaling to decrease the release of CRH and ACTH
5. This decrease is CRH and ACTH, adrenal glands reduce production of glucocorticoids, leading to decrease in cortisol levels in bloodstream
This negative feedback loop helps maintain an approproate balance of glucocorticoids in the body, if cortisol drops the inhibition is lifted allowing for increased scretion to again retsore balance - still a negative feedback loop.
What are the effectors of early stressors?
2 things, both 1 word
- enduring
- irreversible
Tell me about prenatal stress in rats and how this affects offspring?
- Offspring of stressed preggo rats shows increased activation of the HPA axis
- Elevated blood corticosterone concentrations as adults (Henry et al., 1994)
- More likely to be anxious and to self administer drugs (cocain, amphetamines; deminiere et al., 1992)
What does prenatal stress in humans cause in the offspring?
- Reduced birth weight, developmental delays, attentional defiicts, hyperanxiety , impaired coping strategy and impaired social behaviours - Weinstock, 1997
- 1940 invasion int he netherlands, lead to babies who were born after mothers experienced this whilst pregnant led to an increased incidence of schizophrenia - Van Os and Selten, 1998
Neonatal stress in rats - effects on offspring
Early stressful experience affect reactions to stress in later life (stress immunization effect)
e.g. brief separation of rat pups from mother is mildly stressful
Upon return, mother will lick pups more
As adults, these rats pups are better able to cope with stressors than non-separated pups (Liu et al., 1997)
Moderate or severe stressors as pups lead to elevated stress responses (=less coping) throughout life (Rots et al., 1996)
What does early adveristy in humans cause?
case study
Romanin orphanages : Bad conditions of malnutrition, sensory depravation, poor hygeiene, disease and low levels of social interaction
Result : likelihood of long term behavioural problems and ednocrine dysregulation increase with length of institutional experience
Case study on duration of neglect and brain functioning :
Vanderwert et al., 2010
- time spent in orphanage linked to decreases in EEG alpha power which is associated with perception and attention
- placing children into foster care aids recovery but only if the child is below 2 years of age