Stress Flashcards
The term “stress” comes from _____, that borrowed it from _________
Hans Selye, engineering
Stress def
Non specific response of the body to any demand for change.
Stressor
External demand that creates a challenge to homeostasis (physiological equilibrium).
=> Can be ACTUAL dangers or GOOD things (e.g. baby)
Stress response
How the organism reacts both physically or psychologically to a stressor.
Explain Physiological Stress response (general)
Hypothalamus => Sympathetic Nervous System (SNS)
(1) Sympathetic Adrenomedullary System (SAM) => Fast
(2) Hypothalamus-Pituitary-Adrenal (HPA) Axis => Slow
Sympathetic Adrenomedullary System (SAM) in Stress
Rapid fight-or-flight response. Hypo causes inner portion of adrenal glands to secrete ADRENALINE & NORE => Increased excitation of body’s periphery (heart rate, pupils, digestion, glucose…) => Allows organism to escape danger.
Hypothalamus-Pituitary-Adrenal (HPA) Axis in Stress
Slower, manage energy and inflammation. Hypo secrets Corticotropin Releasing Hormone (CRH)→ stimulates the Pituitary gland → secrets Adrenocorticotropic Hormone (ACTH) →Induces the Adrenal cortex to produce Glucortinoids (cortisol) => Aids in fight/flight response (provides organism w energy for sustained escape + INHIBIT immune system)
Allostatic load
Cost for mobilizing stress response. Wear and tear from repeated and long-term stress exposure.
=> Allostatic overload suggests prolonged stress can harm multiple biological systems, increasing disease risk.
Cortisol is critical for brain maturation: (3)
(1) Intente terminal maturation (develop neuronal connections)
(2) Remodel axons and dentrites
(3) Too little or too much cortisol = cell death => Looking for happy medium
Hippocampus function (5)
(1) Very sensitive to stress exposure/response.
(2) Critical to memory, stress regulation.
(3) Shares reciprocal connections with the hypothalamus (major neural controller of endocrine system).
(4) High concentrations of cortisol receptors
(5) Hippocampus helps to regulate HPA axis => If hippocampus damaged, it can result in cortisol hyper-secretion
[Hippocampus]
⇒ Acute stress _____________.
⇒ Chronic stress results in ________________________.
suppresses hippocampal activity, decreased hippocampal volumes
PFC function (2)
(1) Important for decision-making, working memory, self-regulatory behaviors, mood, impulse control.
(2) Slower to develop - Bc it’s in development, it’s easier to inflict damage on that system
[PFC]
=> Repeated stress exposure causes ____________.
=> Chronic stress exposure associated with ______________.
dendritic shortening, decreased volume of PFC (Either through cell death or reduced connections)
Propertiesof stressors closely linked with disease risk (3)
Perceived as:
(1) Uncontrollable
(2) Unpredictable
(3) Severe
Five general patterns of Early Life Stress (ELS)
(1) ELS is common
(2) ELS increases risk for developing a lifetime mental disorder compared to no ELS
(3) ELS is associated with virtually all commonly occurring forms of psychopathology–it appears to benon-specific
(4) ELS is associated with increased vulnerability to psychopathology that persists across the life course
(5) ELS explains a substantial proportion of mental disorder onsets in the population (~30%).