Stress Flashcards
What is the name of the syndrome that describes the stages of stress
General adaptation syndrome (Seyle)
Stages of stress
- Alarm
- Either resistance or exhaustion
What are the hormones related to stress
Adrenaline and glucocorticoids (eg. Cortisol)
What is the permissive effect
It is cortisol enhancing the effects of adrenaline
Function of cortisol
Increase breakdown of glycogen to glucose release
Increase fats and protein breakdown
Anti inflammatory
Immunosuppressive
Increase bone resorption, decrease bone mass
Permissive effects of adrenaline
Does cortisol promote or in]nhibit the release of prostaglandins and leucotrienes
Inhibit
How does anti inflammatory drugs link into stress
Anti inflammatory drugs like corticosteroids disrupts the normal control mechanisms, suppressing CRH and ACTH release, stress response suppressed
What controls cortisol release
HPA axis - hypothalamus-pituitary-adrenal
If we fail to adapt (ie exhaustion phase), what sort of risk are we putting our bodies at?
CVS
Immunosuppressive due to constant cortisol
Adrenal failure may result
Peptic ulcers