Strategy in Synthesis Flashcards
1
Q
What is the pKa of alkyl-H?
A
50 (available base = BuLi)
2
Q
What is the pKa of Ar-H?
A
45
3
Q
What is the pKa of Alkene-H?
A
45
4
Q
What is the pKa of R2N-H?
A
35 (available bases = R2NLi and BuLi)
5
Q
What is the pKa of Alkyne-H?
A
25
6
Q
What is the pKa of Ester -H?
A
25
7
Q
What is the pKa of ketone- H?
A
20
8
Q
What is the pKa of RO-H?
A
15 (available bases= RO- and Na)
9
Q
What is the pKa of Anhydride H?
A
13
10
Q
What is the pKa of Nitro H?
A
10
11
Q
What is the pKa of Carboxylic Acid-H?
A
5
