Strategies in Epidemiology Flashcards
What is time-response relationship?
It is the time period between the exposure and the development or the outcome (incubation period and latency period)
Features of a good hypothesis
A good hypothesis should specify the following:
1 The population to whom the hypothesis will apply
2 The cause being investigated (suspected risk factor)
3 The outcome which is usually the disease or condition of interest
4 The dose-response relationship
5 The time-response relationship
What is the method of concomitant variation?
It involves identifying a factor whose frequency or strength varies with the frequency of the disease.
Draw the epidemiologic approach
(Draw)
How does the hypothesis guide the investigator?
1 limits the area of investigation
2 sensitizes the researcher to relevant data and relationships
3 provides a unifying concept between the variables being investigated
What is the method of analogy?
Uses deductive reasoning when the distribution of disease may be sufficiently similar to some other disease to suggest that certain causes may be common to both
What is a hypothesis?
It is an assertion or proposition about the relationship between two or more variables adopted to explain certain facts and to guide in the investigation of others.
What is a disadvantage of method of difference?
Potentially large number of hypotheses which are consistent with or are suggested by the observed difference
Branches of empirical sciences
Natural sciences
Social sciences
What is dose-response relationship?
It is the amount of exposure necessary for the disease or condition to develop.
Selection of hypothesis for evaluation
(Review)
What is a disadvantage of method of analogy?
It may result in false analogies.
Epidemiologic study designs
(Review)
Consideration in formulating a hypothesis
1 New hypotheses are commonly formed by relating observations from several different fields
2 The stronger the statistical association between the exposure and the disease, the more likely it is to suggest a causal hypothesis
3 Observed changes in the frequency of disease, especially if the change occurs over a relatively short span of time, can lead to a very productive hypothesis
4 An isolated or unusual case should receive particular attention in forming hypotheses
5 Observations that appear in conflict or those which present a paradox should be considered
If two different circumstances result to marked differences in disease frequency and a particular factor can be identified in one circumstance but not in the other, then the presence or absence of this factor may be a cause of the disease.
Method of difference