Stone Disease Flashcards
Nephrolithiasis
general term for renal calculi
Predominant symptom of nephrolithiasis
flank pain due to renal colic. (dilation, stretching, spasm)
Physical Exam findings for nephrolithiasis
severe CVA tenderness pain can migrate to upper/lower ab quadrant (migration of ureteral stone) abdominal exam unremarkable (hypoactive bowel sounds, absent peritoneal signs) painful testicles constant body positional movements tachycardia hypertension microscopic hematuria
Lab Testing for stones
urinary sediment/dipstick test CBC with diff (febrile pts) serum electrolytes (vomiting pts) serum and urinary pH level microscopic UA 24 hr urine profile
Imaging for stones
noncontrast abdominopelvic CT scan renal ultrasound kidney/ureter/bladder xray IVP Retrograde pyelography nuclear renal scanning plain renal tomography
management goals for stones
medical therapy: encourage spontaneous passage of stone. supportive care (pain control/antibiotics)
surgical therapy: completely relieve the obstruction
Medical management for stones
IV hydration antiemetics antibiotics pain control NSAIDS uricosuric agents (allopurinol) antidiuretics alkalinizing agents corticosteroids CCBs alpha blockers
Surgical management
stones greater or equal to 7 mm to pass spontaneously and require some type of surgical procedure: stent placement, percutaneous nephrostomy tube (PNT), extracororeal shockwave lithotripsy, uretoscopy, percutaneous nephrostolithotomy, open nephrostomy
Pathophys of stones
supersaturation mechanism: supersaturation of the urine by stone-forming constituents
majority of renal canculi contain calcium
uric acid calculi and crystals of uric acid, with or without other contaminating lens, comprise the bulk of the remaining minority
calcium oxalate, calcium phosphate, and calcium urate are associated with the following disorders
hyperparathyroidism
increased gut absorption of calcium
renal calcium leak
renal phosphate leak
etiology of stones
low fluid intake
hypercalciuria (most common metabolic abnormality)
magnesium (especially citrate) are important inhibitors of stone formation
4 main chemical types of stones (calcium, struvite, uric acid, cystine)
the most potentially dangerous aspect of stone disease
urinary tract obstruction & upper UTI
pyelonephritis, pyonephresis, and urosepsis
necessitates early recognition and immediate surgical drainage
patients at risk of stone development are counseled to seek immediate medical attention if
he or she experiences flank or abdominal pain
visible bleed in the urine
regularly visiting a HCP who advises preventative treatment plans can
- improve the situation in most patients with stones
- strongly motivated to follow a program for maximum kidney stone prophylaxis
- merely increasing fluid intake and can cut the stone recurrence rate by 60%
- phenomenon known as the stone clinic effect
- optimal use of metabolic testing with proper eval and compliance with therapy can completely eliminate new stones in many pts
- significantly reduces new stone formation in most patients
urologic emergency
- complete urinary tract obstruction
- obstruction in a solitary kidney
- obstruction with fever, infection, or both
- renal failure
- pain that is uncontrolled with oral meds
- n/v that causes dehydration