Stomach Flashcards
Gastric cancer presentation
- weight loss
- epigastric abdominal pain
- dysphagia (if at EGJ)
- nausea and early satiety
- occult GI bleeding
- Virchows node (supraclavicular)
- Sister Mary Joseph’s node (periumbilical)
- left axillary node
- Krukenberg tumor (enlarged ovary or ovarian mass)
- Blumers shelf (mass in rectal cul de sac)
Gastric cancer work up and staging
- barium swallow
- CT
- EGD with biopsy
- Staging
- CT chest/abd/pelvis for mets
- EUS for T and N stage
- if T2N0 or higher, PET/CT
- staging laparoscopy (on patients with more than T1 lesion on EUS and no evidence of stage IV disease)
TNM stages Gastric cancer
T1a invades lamina propria
T1b invades submucosa
T2 muscularis propria
T3 subserosa
T4 through serosa
N1 1-2 LN
N2 3-6 LN
N3 > or = 7
what makes a gastric cancer unresectable
- peritoneal involvement
- distant mets
- paraaortic LN +
- invasion of major vascular structure (such as aorta)
- encasement or occlusion of hepatic a. or celiac axis
- distal splenic vessels are NOT unresectable
when do you give neoadjuvant chemo to gastric cancer patients
who gets post op chemo/xrt
neoadjuvant
- > or = T2
- any + LNs
adjuvant chemo/radiation (5FU)
- resected T2-4 cancer
- node positive gastric ca if less than a D2 LN resection was done
- what are risk factors of gastric cancer
- what is Lauren classification
- what is significant about being CDH1 autosomal dominant
- H. pylori, nitrates, salt
- intestinal type and diffuse type
- prophylactic gastrectomy and increase risk of breast cancer
Surgical resection of gastric cancer
- distal tumors (distal 2/3 of stomach)
- partial gastrectomy with LN resection
- proximal tumors
- total gastrectomy
- LN resections: D2
- includes D1 (perigastric)
- includes D2 (left gastric a, common hepatic a., celiac a., splenic hilum and splenic a.)
- goal is examining of 15 LN or more
list post-gastrectomy anastomosis complications
Anastomosis complications
- duodenal stump leak
- stricture
- afferent loop syndrome
- efferent loop syndrome
- jejunal intussesception
- internal hernia
- marginal ulcer
list post gastrectomy transit complications
- dumping
- post vagotomy diarrhea
- gastric stasis
- alkaline gastritis
- roux stasis syndrome
describe dumping syndrome
Early dumping
- 10-30 min after food
- hyperosmolar chyme dumped into small bowel
- N/V, crampy pain, belching
- diaphoresis, palpitations, flushing
Late Dumping
- hypoglycemia following post prandial insulin peak
- hours post food
- same symptoms
treatment of dumping syndrome
small frequent meals high in fiber and protein
octeotride MAY help
if fails medical therapy⇒Roux en Y gastroJ
how do you treat duodenal stump leak?
- if early
- emergency surgery
- duodenostomy, drainage, NPO, TPN
- emergency surgery
- if late (more than a week of sx)
- drain with CT guidance, NPO, TPN
describe sx and diagnosis of afferent loop syndrome
- mechanical obstruction of afferent limb
- RUQ pain, non bilious vomiting, pain relieved with bilious emesis
- diagnosis: CT scan shows dilated afferent limb
how do you treat afferent loop syndrome
- convert to roux en y or Braun enteroenterostomy
- can also decrease length of afferent limb
describe pathophys, sx and dx of efferent loop syndrome
- causes gastric outlet obstruction
- sx: epigastric pain, distension and bilious vomiting
- dx: CT scan or UGI series
- tx
- balloon dilation
- or find obstruction and relieve it