Stomach Flashcards
Give a differential for thickened, lobular folds in the body and antrum
Gastritis - H. pylori
Zollinger-Ellison
Lymphoma
Which ulcer is h. pylori more associated with?
Duodenal (90%) vs Gastric (70%)
Give a differential for small, round, filling defects with a small central collection of barium
Erosive (varioloform) gastritis Barium precipitate (dont have mound of edema) Crohns (will have other lesions)
What are the features of a benign gastric ulcer
Round or oval crater
Folds that CROSS the mound of surrounding edema
Symmetric and smooth filling defect surrounding the crater
Extension of the ulcer beyond the normal gastric lumen contour
Smooth and symmetric radiating gastric folds
Where do most benign ulcers occur
Along the lesser curvature or posterior wall of the antrum/body
Benign ulcers along the greater curvature are associated with what
aspirin coated medication
What is a hamptons line
Line of nonulcerated acid-resistant mucosa around the ulcer crater - BENIGN feature
How does a healing ulcer presents? When do they start to heal?
Linear configuration
Can split into 2 smaller crates as reepitheliazation occurs
8 weeks
What are the signs of a healed ulcer?
Radiating folds with retraction indicates fibrosis
Area gastricae in the scarred region
What is a benign sump ulcer? Differentiate between an intramural diverticulum.
An ulcer crater in the dependent stomach along the distal greater curvature (like a sump collection)
Usually due to medication
Smooth surfaced and tapers gradually. Surrounding edema has abrupt margins
Diverticulum will change shape with peristalsis and not have surrounding edema
What size is a giant ulcer? Is there any prognostic indication based on size? multiplicity?
> 3cm
Size doesnt matter
Multiple favor benign cause, but should be evaluated individually
What are the major complications of gastric ulcers?
Bleeding - most common
Perforation
Obstruction
Perforation with fistula formation
What is the most common cause of gastrocolic fistulas?
Primary carcinoma of stomach or colon
Differentail for enlarged rugal folds, hypersecretion, peptic ulcers, and thickened folds in the proximal small bowel
Zollinger - ellison
Lymphoma
Gastric Ca - focal mass or narrowing
Menetrier - proximal stomach only
What is zollinger - ellison syndrome?
Pathology
How many are malignant?
What associated sydrome? How many?
Symptoms
Diagnostic test?
Gastric secreting islet cell neoplasm
Marked hypersecretion of HCl with peptic ulcer disease
50% are malignant
1/4 have MEN1 (parathyroid, pitiutary, pheochromocytoma)
Intracatble peptic ulcer disease with malabsorption
Paradoxical increase in gastrin with secretin injection
What is an aphthous ulcer? What is it seen in ?
Central ulceration with surrounding mound of edema
Crohns (will have other GI involvement)
Erosive gastritis
Markedly enlarged gastric folds in the proximal stomach?
Menetrier disease (hypertrophic gastropathy)
Hyperplasia of surface epithelial cells with abundant mucus cells. Results in achlorhydria due to replacement of parietal cells.
Folds will be organized and follow distribution of normal rugae (unlike lymphomatous proliferation)
What is a differentiating feature between hyperplastic and adenomatous gastric polyps?
What do multiple small polyps designate?
Hyperplastic - multiple, 1cm, usually carry malignant potential if >2cm
Innumerable - FAP
What types of gastric polyp is seen in FAP? Duodenal polyp?
Gastric - hyperplastic
Duodenal - adenomatous
What are the two main variations of FAP?
Gardner - FAP, desmoid tumors, osteoma, epidermoid cysts, papillary thyroid
Turcot - FAP, CNS tumor (gliomas, medulloblastomas)
What type of polyp is seen in FAP associated symdromes?
The other polyposis syndromes? (canada chronkite, peutz jeugher)
Hyperplastic
Hamartomas
What are the following syndromes?
Mucocutaneous pigmentation, GI malignancy, gynecologic malignancy
Mucocutaneous lesions, thyroid abnormalities, breast abnormalities
Stomach, small bowel, colon, ectodermal changes (skin, hiar, nails)
Peutz-Jeugher
Cowden
Cronkhite-Canada
Differential for well demarcated, smooth surfaced mass
Submucosal tumor
GIST (most common submucosal gastric tumpor) Lipoma Fibroma Carcinoid Neurogenic tumors, leiomyoma
What characteristics help differentiate a malignant GIST?
Size - >10cm
Irregular shape
Central necrosis