Stomach Flashcards
Eponym of the left vagal trunk
Continues as nerve of Latarjet
Gives hepatic branch
Eponym for right vagal trunk
Continues as the criminal nerve of Grassi
Gives celiac branch
*culprit in ulcer recurrences following truncal vagotomy?
Produces somatostatin
D cells
Produces serotonin
Enterochromaffin cells
Products of parietal cells
“Oxyntic cells”
Hydrochloric acid
Intrinsic factor
Products of chief cells
“Zymogenic cells”
Pepsinogen
Gastric lipase
Leptin
Majority of gastrinomas are found here
Passaro triangle “Peptic-Causing Disease” Pancreas (junction of neck and body) Cystic duc and CBD jxn Duodenum 2 & 3 junction
Diagnostics for gastrinoma
- Elevated fasting serum gastrin and BAO (Basal Acid Output)
- Confirmatory test: secretin stimulation test (gastrin >200 pg/mL after IV secretin administration)
- Rule out the presence of MEN1 – Ca and PTH levels
- Preoperative imaging/localization: octreotide scan
Treatment of gastrinoma
Sporadic cases: resection
Familial cases: surgical debulking to ameliorate symptoms
Algorithm for forrest classification
Ia-IIb: endoscopic treatment, intensive PPI, clear fluids for ~ 2 days, hospitalize 3 days
IIc: no endoscopic threapy, OD PPI, clear fluids for ~ 1 day, hospitalize for ~1-2 days
III: no endoscopic therapy, OD PPI, REGULAR DIET, DISCHARGE after endoscopy
Define INTENSIVE PPI
Intravenous bolus (80 mg) followed by infusion (8 mg/h) for 3 days; 3️⃣ or oral or intravenous bolus (e.g., 80 mg) followed by intermittent high doses (e.g., 40–80 mg bid or 40 mg tid) for 3 days 3️⃣ Then twice-daily PPI on days 4–14 followed by once-daily PPI.
Pharmacologic treatment for bleeding esophageal varices
Intravenous 50 mcg bolus followed by 50 mg/h infusion for 2–5 days.
Dumping syndrome
Caused by destruction of the pyloric sphincter causing abrupt delivery hyperosmolar load to the small intestines
Early dumping
-15-30mins post-ptrandial
-shock-like symptoms d/t peripheral and splanchnic vasodilation
Relieved by saline or recmbency
-diarrhea then follows
Late dumping (2-3 hours post-prandial
-due to hyperinsulinemia with reacitve hypolgycemia
-relieved by glucose administration
Treatment for dumping syndrome
Nonsurgical Earl dummping: octreotide Late dumping: a-glucosidase Surgical Conversion to roux-en-y anastomosis
Triad of bile relfux gastritis
Constant epigastric pain, nausea, bilious emesis
*most commonly assoc’d with billroth II gastrojejunostomy
Surgery: braun entero-enterostomy