Stimulatns&treatment of Headache Flashcards
amphetamine like drugs
- amphetamine found to produce weight loss in early studies of pts with narcolepsy
- rate of weight loss is increased by ~ 0.5 pound per week
- efficacy is similar btwn drugs
- no long -term weight loss unless the drugs are taken continuously
SE of amphetamine like drugs
- potential for drug abuse and habituation
- exacerbation of HTN
- sleep disturbances
- palpitations
- dry mouth
MOA of methamphetamine
- releases dopamine, other biogenic amines
- inhibits neuronal and vesicular monoamine transporters
- inhibit MAO
- CNS stimulants w/ little peripheral effects at low doses compared to amphetamine
- high dose inc. BP and Inc. cardiac output
SE of methamphetamine
high abuse potential HTN Tachycardia Increased risk of stroke, MI Insomnia
indications of methamphetamine
- exogenous obesity
- short term adjunctive therapy for pts refractory to standard therapies (repeated diets and other drugs)
contraindications of methamphetamine
CV disease, HTN, hyperthyroidism, history of drug abuse
methamphetamine drug interactions
- should not be combined w/ MAOs or other NS stimulants
- decrease effectiveness of guanethidine used to treat hypertension
MOA of phentermine
- sympathomimetics, CNS stimulant
- increased NE release from central noradrenergic neurons
effectiveness of phentermine
- 2-10kg loss of original wt as long as the drug is taken
- weight regained once therapy ceases- used chronically
AE of phentermine
- dry mouth, insomnia, constipation
- HTN, tachycardia
- abuse liability thought to be low
drug interactions
MAOIs, guanethidine, other CNS stimulants, alcohol, sibutramine and tricyclic antidepressants
contraindications of phentermine
HTN, advanced CV disease, hyperthyroidism, glaucoma, anxiety and history of drug abuse
MOA of Sibutramine
inhibits the reuptake of NE, serotonin, dopamine
effectiveness of Sibutramine
10% loss of original wt as long as the drug is taken
-wt regained once therapy ceases-used chronically
AE of Sibutramine
- dry mouth, insomnia, constipation and asthenia
- Hypertension and tachycardia-required monitoring
what are the SSRI antidepressants
- fluoxetine
- setraline
- paroxetine
MOA of SSRIs
- increase wt loss in combo w/ caloric restriction for up to a yr
- wt gain associated w/ long term use
what is Bupropion (Wellbutrin SR)
- non SSRI antidepressant
- modestly effective when added to a program of caloric restriction
what are the Antiepileptic drugs
Topiramate
Zonisamide
MOA of Topiramate
- produce wt loss in pts w/ epilepsy
- increased wt loss in combo w/ caloric restriction: up to 6.3% in 6 months
- longer durations and higher doses are more effective, but can be associated w/ adverse neurological and psychiatric effects
MOA of Zonisamide
- shown to produce wt loss when used in treating epilepsy
- significantly increased wt loss w/ caloric restrictions: 6 kg over 16 wks
what drugs are used for Narcolepsy
amphetamine
dextroampheamine
methamphetamine
what are the AE of narcolepsy drugs
development of tolerance, abuse, potential, irritability, depression, paranoia
what drugs can be used to treat ADHD
methylphenidate
dextroamphetamine
amphetamine
what are the AE of ADHD
insomnia, wt loss, growth impairment