opioids Flashcards
1
Q
what is an opiate
A
derived form alkaloids of the opium poppy
2
Q
what is an opioid
A
natural and synthetic drug which mimic morphone
3
Q
what ia analgesia
A
state in which no pain is perceived despite the presence of a stimulus that would normally cause pain
4
Q
what is the MOA of opioid analgesics
A
- act by binding to receptors for endogenous opioids
- G protein of adenylyl cyclase activity
- close presynaptic voltage gated Ca++ channels
- reduces neurotransmitter release of: NE, substance P, Ach, glutamate, serotonin
- open postsynaptic K+ channels; hyper polarizes and inhibits activity
5
Q
what are the endogenous opioid peptides
A
- Enkephalins (from the head)
- Endorphins (endogenous opiate)
- Dynorphins (dynamic opiate)
6
Q
what is the precursor of enekphalins
A
proenkephalin
7
Q
what is the precursor of endorphins
A
proopiomelanocortin
8
Q
what is the precursor of dynorphins
A
prodynorphin
9
Q
where are endogenous opioid precursors found
A
at sites associated w/ pain modulation
10
Q
where do endogenous opioid peptides action occur
A
-effects occur at the spinal and supra spinal levels and at the peripheral endings of sensory nerves
