Stimulation of gonadal functions

Question 1

List the GnRH anologues?

Answer 1

Gonadorelin

Buserelin

fertirelin

Lectirelin

Desorelin

Question 2

what is the function of the GnRH anologues?

Answer 2

stimulates the production and release of LH and FSH

Question 3

describe the application of GnRH anologues?

Answer 3

SC, IM (Eq-IV)

SC implants used for chemical castration

Question 4

which GnRH is used for chemical castration?

Answer 4

Desorelin

Supreorin implant

male dogs

6 month duration

Question 5

describe the uses of the GnRH anologues?

Answer 5

1. reduce the time interval from calving to first ovulation
2. Treatment for ovarian follicular cysts in dairy cattle
3. chemical castration
4. sexual development
5. induction of polyestrus
6. increase sperm quality
7. to control the time of ovulation at the end of synchronisation programmes

Question 6

describe the side effects of GnRH anologues?

Answer 6

hyperthermia

allergic reactions

Cysts on the CL

should not be used in pregnant animals (can cause abortion)

Question 7

name the anterior pituitary gonadotrophins?

Answer 7

LH and FSH

Question 8

describe the effects of FSH?

Answer 8

• in females:
  
  • in the ovaries, increase in growth of follicle and oestradiol production
• in the males:
  
  • increases spermatogenesis in testicles

Question 9

Describe the effects of LH?

Answer 9

• In females:
  
  • final maturation of the follicle - oestrogen production, ovulation, luteotropic in most domestic species
• In the males:
  
  • increase in testosterone production by the leydig cells

Question 10

list the uses of LH in veterinary medicine?

Answer 10

To induce ovulation

To luteinize follicular cysts

To induce follicular growth and ovulation

Question 11

list the veterinary uses for FSH?

Answer 11

to induce follicular growth for the purpose of supra-ovulation in donor cows used for embryo transfer

Question 12

Name the non-pituitary gonadotrophins?

Answer 12

Pregnant mare serum gonadotrophins (PMSG, eCG)

Human chorionic gonadotrophin (hCG)

Question 13

describe the veterinary used of PMSG?

Answer 13

FSH like activity

• Females:
  
  • to induce follicular growth and ovulation
  • for superovulation
• Males:
  
  • to stimulate spermatogenesis and libido

Question 14

describe the veterinary uses for hCG products?

Answer 14

Predominantly LH like activity

• Females:
  
  • to cause ovulation in the mare at the time of breeding
  • for the treatment of nymphomania due to cystic ovaries
  • For ovulation stimulation
• Males:
  
  • for the treatment of cryptorchidism (increase in testosterone production of single testicle)

Question 15

name the veterinary PMSG products?

Answer 15

PG 600 inj.

Question 16

name the veterinary hcG product ?

Answer 16

PG 600 inj.

Pregnyl inj.

Question 17

name the groups of drugs used for oestrus synchronisation?

Answer 17

1. Progestogens/ Progestagens
2. Prostaglandins

Question 18

name the progestogens/progestagens used for oestrus synchronisation?

Answer 18

• 1st generation:
  
  • Progesterone
  • MPA
  • Norgestomet
  • Flugestone acetate
  • Altrenogest
• 2nd generation
  
  • Proligestone
  • Megestrol acetate

Question 19

name the prostaglandins used for oestrus synchronisation?

Answer 19

Cloprostenol

Dinoprost

Etiproston

Luprostiol

Question 20

name the uses of progestagens/ progestogens and prostaglandins other than oestrus synchronisation?

Answer 20

1. To suppress oestrus and ovulation in companion and farm animals
2. Treatment against pyometra
3. Treatment against endometritis
4. Abortion
5. induction of parturition