Stimulants

Question 1

Guanfacine helps to improve ADHD symptoms by acting on [location] a2 receptors

Answer 1

Guanfacine helps to improve ADHD symptoms by acting on post-synaptic a2 receptors

Question 2

Atomoxetine is an ADHD drug that works by [MoA]

Answer 2

Atomoxetine is an ADHD drug that works by inhibiting NET
* Decreases NE reuptake

Question 3

Methylphenidate is an ADHD drug that works by [MoA]

Answer 3

Methylphenidate is an ADHD drug that works by inhibiting NET and DAT
* Reduces the reuptake of both NE and DA

Question 4

The most concerning toxicity of methylphenidate in children is _

Answer 4

The most concerning toxicity of methylphenidate in children is weight loss/ growth suppression

Question 5

Amphetamines help in the treatment of ADHD by [MoAs]

Answer 5

Amphetamines help in the treatment of ADHD by inhibiting monoamine reuptake and stimulating their release
* All monoamines, serotonin, NE, DA have a role in treating ADHD

Question 6

How does amphetamine and dexamfetamine treat narcolepsy?

Answer 6

Increase in DA and NE –> decrease in GABA –> increased His and wakefulness

Question 7

_ and _ are two circulatory side effects of amphetamines

Answer 7

angioedema and raynaud phenomenon are two circulatory side effects of amphetamines

Question 8

CNS effects of amphetamines include:

Answer 8

CNS effects of amphetamines include:
* Decreased appetite
* Dependence
* Agitation, panic, delirium, psychosis
* Insomnia

Question 9

SNS toxicities of amphetamines include:

Answer 9

SNS toxicities of amphetamines include:
* Tachycardia
* Arrhythmias
* HTN

Question 10

Modafinil is an off-label treatment of ADHD that works by _

Answer 10

Modafinil is an off-label treatment of ADHD that works by stimulating DA signaling
* By an unclear mechanism

Question 11

Caffeine is an antagonist of _ receptors

Answer 11

Caffeine is an antagonist of adenosine receptors
* Therefore stimulates the reticular activating system