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Reproductive > STI Drugs > Flashcards

STI Drugs Flashcards

1
Q

drug of choice for HSV

A

acyclovir, valacyclovir

foscarnet (acyclovir-resistant pt)

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2
Q

acyclovir adverse effects

A

neurotoxic, nephrotoxic

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3
Q

drug of choice syphilis

A

IM PCN G (single dose for primary, early latent; 3 wks for late latent; 10 days for congenital)

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4
Q

Sudden onset of fever, chills, headache, myalgias shortly after PCN given to pt w/ secondary syphilis

A

Jarish-Herxheimer rxn to lysis of treponemes
Nl rxn, common
DO NOT stop PCN

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5
Q

chlamydia drug of choice

A

azithromycin

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6
Q

azithromycin/erythromycin MOA

A

bind 50S ribosomal subunit –> prevents protein synthesis

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7
Q

doxycycline MOA

A

binds 30S ribosomal subunit –> prevents protein synthesis

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8
Q

quinolone MOA

A

inhibits topo II (gram-neg) or topo IV (gram-pos)

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9
Q

weird stuff w/ erythromycin

A

short half life
inactivated by gastric acid
CYP metabolism
associated w/ hypertrophic pyloric stenosis

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10
Q

doxycycline adverse effects

A

hepatic damage, photosensitivity

teratogenic

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11
Q

drugs of choice for chancroid

A

azithromycin
ceftriaxone
cipro
erythromycin

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12
Q

ceftriaxone MOA

A

beta-lactam

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13
Q

drug of choice for GC below the belt

A

ceftriaxone or cefixime plus

CT drugs

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14
Q

drug of choice for GC pharyngitis

A

ceftriaxone plus CT drugs

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15
Q

drug of choice for trich

A

metronidazole

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16
Q

metronidazole MOA

A

disrupts DNA helical structure

CYP metabolism

17
Q

metronidazole adverse effects

A

disulfiram-like effect

avoid in pregnancy/breastfeeding

18
Q

drug of choice for bacterial vaginosis (Gardnerella)

A

metronidazole

19
Q

drug of choice for candida

A

azole antifungal (esp fluconazole)

20
Q

drugs for HPV

A

imiquimod (immune modulator)
podofilox (mitotic spindle inhibitor)
sinecatechins (green tea antioxidant)

Reproductive (8 decks)

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