Prostate Cancer Drugs

Question 1

GnRH agonists

Answer 1

Goserelin, Histrelin, Leuprolide, Triptorelin

Question 2

GnRH agonist MOA

Answer 2

continuous (rather than pulsatile) levels of GnRH –> decreased FSH/LH
work within 2-4 wks

Question 3

GnRH adverse effects

Answer 3

decreased bone density
elevated lipids, weight gain, DM
gynecomastia, decreased libido, sex dysfunction
teratogenic

Question 4

GnRH antagonist and MOA

Answer 4

Degarelix

blocks GnRH receptors; effects within 3 days, no dz flare like w/ GnRH agonists

Question 5

GnRH antagonist adverse effects

Answer 5

QT prolongation

Question 6

Estramustine MOA

Answer 6

binds estramustine binding protein on prostate cancer –> delivers alkylating agent –> inhibits microtubules

Question 7

Estramustine adverse effects

Answer 7

increased estradiol levels –> gynecomastia, impotence, increased risk of VTE, MI, and stroke

Question 8

androgen receptor blockers

Answer 8

Bicalutamide, Enzalutamide, Flutamide, Nilutamide

Question 9

Bicalutamide adverse effects

Answer 9

GI toxicity, hepatotoxic, teratogenic

Question 10

Enzalutamide adverse effects

Answer 10

CNS sx, URI, GI toxicity, teratogenic

Question 11

Flutamide adverse effects

Answer 11

blood dyscrasia, hepatotoxic, GI toxicity, teratogenic

Question 12

Nilutamide adverse effects

Answer 12

heart failure, blood dyscrasia, GI toxicity, hepatotoxic, interstitial pneumonitis, accomodation to dark impaired

Question 13

Sipuleucel-T MOA

Answer 13

stimulates production of T cells against prostatic acid phosphatase (prostate cell antigen)

Question 14

Abiraterone MOA

Answer 14

inhibits 17a-hydroxylase –> decreased androgen production

Question 15

Abiraterone adverse effects

Answer 15

mineralocorticoid excess (HTN, K wasting)
elevated LFTs
teratogenic (female and male)

Question 16

conventional chemo used

Answer 16

Docetaxel, Carbazitaxel (penetrates BBB), Mitoxantrone