steroids

Question 1

mechanism of fludrocortisone

Answer 1

binds aldosterone receptor which increases Na/K ATPase expansion and increase epithelial Na channels

Question 2

mechanism of action of amiogluthimide

Answer 2

blocks conversion of cholesterol to pregnelone

Question 3

mechanism of ketoconazole

Answer 3

potent inhibit of adrenal & gonadal steroid synthesis

Question 4

what is a major SE you are worried about with keoconazole

Answer 4

hepatotoxicity

Question 5

mechanism of action of mitotane

Answer 5

nonselective cytotoxic action of adrenal cortex

Question 6

why isn’t mitotane used anymore

Answer 6

bad SE profile

Question 7

action of metyrapone?

Answer 7

-selective inhibitor of 11 hydroxlation (interfering with cortisol to corticosterone synthesis)

Question 8

action of mifepristone

Answer 8

glucocorticoid receptor antagonist at high levels

Question 9

what is mifepristone good for treating

Answer 9

good for hyperglycemia due to high cortisol

Question 10

action of pasireotide

Answer 10

somatostatin analog. blocks release of ACTH

Question 11

what is pasireotide used for?

Answer 11

cushings disease (pituitary souse)

Question 12

what are the 2 aldosterone receptor antagonists used for treatment of aldosteronism?

Answer 12

spirnolactone

epierenone