parathyroid hormone Flashcards
What are the indications for the use of bisphosphonates?
- hypercalcemia
- osteoporosis
- pagets disease
- osteogenesis imperfecta
What is the method of action of bisphosphonates?
reduce osteoclastic resorption of bone
What is the main side effect of most bisphosphonates?
GI irritation
Which bisphosphonates are able to bypass the GI tract?
zoledronic acid and pamidronate
When would you use a calcimimetic?
- secondary hyperparathyroidism from renal disease
- parathyroid carcinoma
- hypercalcemia in primary hyperPTH not treatable by surgery
What is the function of a calcimimetic?
reduces PTH and serum calcium
When would you use calcitonin?
short term relief of hypocalcemia
-osteoporosis or pagets disease
what is the function of calcitonin?
inc calcium excretion, inhibits resorption of bone
What form of calcitonin is no longer used and why?
nasal spray - increases risk of cancer
Which drug is a PTH analog?
teriparatide
What is the indication for teriparatide?
osteoporosis high risk patients who have failed other therapies
What are the s/e of teriparatide?
mild hypercalcemia
inc risk of osteosarcoma in rats
Which drug is a SERM?
raloxifene
What is the method of action of corticosteroids?
dec production of 1,25 vit D
What are the indications for corticosteroids?
hypercalcemia from:
vit d toxicity
granulomatous disease
hemat malignancies
