Steroidal Anti-Inflammatory Drugs

Question 1

Cortisol effect on sugar levels

Answer 1

increase

Question 2

Cortisol effect on protein levels

Answer 2

decrease

Question 3

Cortisol effect on fat levels

Answer 3

increase peripherally until pathologic –> increase centrally

Question 4

Cortisol effect on bone levels

Answer 4

decrease

Question 5

GC side effects (general)

Answer 5

adrenal gland suppression and Iatronic Cushing’s disease

Question 6

MC side effects (general)

Answer 6

HTN, hypokalemia, metabolic alkylosis

Question 7

PGI2

Answer 7

pain, cox-2

Question 8

PGE2

Answer 8

pain and fever, cox-2

Question 9

TXA2

Answer 9

platelets, cox-1

Question 10

why to give cox-1 inhib

Answer 10

antithrombotic

Question 11

why to give cox-2 inhib

Answer 11

anagesic, anti-pyretic, anti-inflamm

Question 12

Cortisol

Answer 12

• emergencies

- 1:1 GC/MC

Question 13

prednisone

Answer 13

• steriod burst tx –> activated

5: 1

Question 14

methylprednisolone (Medrol)

Answer 14

-minimal MC

Question 15

Dexamethasone (Decadron)

Answer 15

most potent

min MC

Question 16

Triamcinolone (Kenalog)

Answer 16

• potent
• topical
• no MC

Question 17

Tx of RA with a GC

Answer 17

acts as a bridge

Question 18

GCs adv and disadv

Answer 18

suppresses chronic inflammation and autoimmune attack BUT decreases healing and immunological response