Chemical Mediators of Inflammation Flashcards
1
Q
Vasodilators
A
PG, NO, histamine
2
Q
increased vascular permeability
A
histamine/seratonin, C3a and C5a, Bradykinin, leukotrines (C4,D4, E4), PAF, substance P
3
Q
chemotaxis
A
TNF, IL-1, chemokines, C3a, C5a, leukotrine B4
4
Q
Tissue damage
A
lysosomal enzymes, ROS, NO
5
Q
fever
A
IL-1, TNF, PG
6
Q
pain
A
PG, bradykinin
7
Q
in tissue (preformed)
A
histamine (mast, BAs), serotonin (platelets), lysosomal enzymes
8
Q
in tissue (newly synthesized)
A
PG, leukotrines, PAFs, AOS, NO, cytokines
9
Q
made in the liver
A
factor XII –> bradykinins and coag/fibrin
complement –> C3a and C5a = anaphylax and C5b–> C9 = MAC
