Steroid Hormones Flashcards
1
Q
Define a steroid hormone
A
a type of lipid-soluble hormone derived from cholesterol that acts as a signalling molecule in the body
2
Q
Mechanism of steroid hormone effecting gene expression
A
- steroid hormone diffusion through plasma membrane
- bind to intracellular receptor, change it’s conformation
- hormone-receptor complex formed
- binding to hormone response elements
- recruitment of coactivators/repressors
- regulation of gene transcription
3
Q
The cell-specific physiological responses controlled by intracellular/nuclear receptors is governed by three parameters:
A
Cell-specific expression of nuclear receptors
Localised bio-availabilty of ligands
Differential accessibility of target gene DNA sequences in chromatin to nuclear receptor binding
