Sterile Compounding II

Question 1

Vials have a rubber stopper. If the med contained in a vial would undergo a chemical reaction with rubber, what type of container could the manufacture use instead?

Answer 1

an ampule

an all-glass container

Question 2

What are some examples of unwanted particles that filters are helpful in removing?

Answer 2

glass particles, rubber fragments, dust, clothing fibers, fungi, and bacteria

Question 3

What is a micron?

Answer 3

is a measure of length equal to one one-millionth of one meter

Question 4

What pore size is optimal for removing microorganisms, such as bacteria & fungi?

Answer 4

0.22 micron filter

Question 5

What is total parenteral nutrition? (TPN)

Answer 5

nutrients delivered via intravenous route for the purpose of bypassing the gastrointestinal tract

Question 6

What is the difference between a TPN and a TNA (total nutrient admixture)?

Answer 6

• TPN- is a 2-in-1 mixture of amino acid & dextrose

* TNA- is a 3-in-1 mixture which includes the above plus fat (lipid) component

Question 7

What would happen if you used a 0.22 micron filter on a TNA (3-in-1)?

Answer 7

filter would get clogged by the fat component of the TNA

Question 8

What is the optimal pore size for filtering an infusion that contains?

Answer 8

1.2 microns

Question 9

When compounding a TPN or TNA, how can you minimize the risk of calcium phosphate precipitate formation?

Answer 9

by adding phosphate toward the beginning of t he compounding process & adding calcium last

Question 10

What issue must be considered when including insulin in a TPN or TNA?

Answer 10

up to 50% of the insulin will bind to the surface of the inside of the bag & administration system (tubing)

Question 11

What can happen when Vit C is included in a TPN or TNA?

Answer 11

over time, ascorbic acid degrades to oxalate, which quickly binds with calcium to form a insoluble precipitate called calcium oxalate