Step 2 Flashcards
4 Ts of mediastinal masses
Find mobile, teratoma, thyroid neoplasm, and terrible lymphoma
ACA stroke syndrome
contralateral motor and sensory deficits that are more pronounced in the lower limb than the upper limb
Acid-base status in adrenal insufficiency
Non-anion hyperkalemic and hyponatremic metabolic acidosis
adenomyosis
presence of endometrial glands in the uterine muscle
affects of increase of pH on ionized calcium
causes more to be bound to albumin
aldosterone in central adrenal insufficiency
relatively preserved in these patients
ALL cell characteristics
PAS positive material, TdT staining positive in 95%
amiodarone toxicitiy
pulmonary fibrosis, thyroid dysfunction, hepatotoxicity, corneal deposits, and skin discoloration
analgesia nephropathy
chronic analgesia use causes papillary necrosis in the kidneys
antibody: primary billiary cirrhosis
anti-mitochondiral antibody
antipsychotic that disrupts thermoregulation and body shivering
fluphenazine IM for poor compliance
aortic stenosis murmur
crescendo-decrescendo murmur at the LLSB
APGAR scores that require further evaluation and resuscitation
<7
ARDS dx criteria
bilateral infiltrate, PCWP <200
area of the intestine that the D-xylose test evaluates
proximal small intestine (celiac’s disease)
associated with dermatomyositis
internal malignancies; MC ovarian
atypical antipsychotic to most likely cause EPS
risperidone
azathioprine toxicity
dose related diarrhea, leukopenia, and hepatotoxicity
Background or simple diabetic retinopathy
Microaneurysms, hemorrhages, exudates, and retinal edema
Baker cyst
excessive fluid production by inflamed synovium, occurs in RA, osteoarthritis, and cartilage tears
Basic labs after diagnosis of hypertension
UA, chemistry panel, lipid profile, baseline EKG
best test for detection of fetal chromosomal abnormalities in first trimester
CVS
best test: primary amenorrhea with presence of uterus
FSH
best way to monitor respiratory status in GBS
vital capacity
biliary consequence of TPN
causes gallbladder stasis and predisposes gallstone formation/bile sludging
blastomycosis cutaneous findings
verrucous or ulcerativew
breastfeeding contraindications
Active untreated TB; HIV; active illicit drug/EtOH abuse
bronchial breath sounds
have full expiratory phase
BUN and creatinine changes during pregnancy
Increase in renal plasma flow and glomerular filtration rate
calcification in fate necrosis
coarse (micro in malignancy)
Calcium oxalate stone predispositions
Small bowel disease, surgical resection or chronic diarrhea; leads to malabsorption of that is the bile salts
cardiac consequences of hemochromatosis
dilated or restrictive cardiomyopathy, conduction defects
cardiac manifestations of Friedrich Ataxia
necrosis and degeneration of muscle fiber; can lead to t-wave inversion/myocarditis
carpal tunnel pathophysiology
deposition of mucopolysaccharide protein complexes in the sheathes of the median nerve
cause of amaurosis fugax
retinal emboli from the ipsilateral carotid
Cause of ascending aortic aneurysms
cystic medical necrosis of connective tissue disorder
cause of calcium oxalate crystal in urine
ethylene glycol poisoning
cause of central primary amenorrhea (low FSH)
pituitary
cause of heat stroke
thermoregulation failure
cause of hydatid cysts
echinococcus granulosus
cause of hyponatremia in central adrenal insufficiency
excessive ADH production from the posterior pituitary
cause of hypotension after epidural
sympathetic fiber block that results in vasodilatation of the lower extremity vessels
cause of premature adrenarche
premature androgen secretion of the adrenal gland
cause of primary dysmenorrhea
increased levels of prostagladins during the breakdown of endometrium
cause of secondary amenorrhea
estrogen deficiency
cause of sickle cell aplastic crisis
infections; e.g. parvo
cause of synringomylia
cavitation of the central cord
causes of exudative effusions
infection, malignancy, PE, connective tissue disease, and iatrogenic causes
Causes of hypercalcemia in malignancy
osteolytic mets, increase PTH-related protein, increased 1,25 vit D and increased IL6
Causes of hypoparathyroidism
Postsurgical, autoimmune, defective calcium sensing
causes of macrocytic anemia with hypersegmented neutrophils
folic acid or cobalamin deficiencies
CD-19 cells
B-lymphocytes
CD-3 cells
T-lymphocytes
celiac’s disease antibody
anti-endomysial
Cervical mucous during the ovulating phase
profuse, clear and thin; will stretch 6cm and exhibit ferning
change in L-thyroxine in patients receiving HRT
increases due to increased liver enzyme production, increased TBG, and increased volume of distribution of thyroid hormone
characteristic microscpoic findings for membranoproliferative glomerulonephritis
dense intramembranous deposits that stain for C3
clopidogrel indications in CAD
1 year s/p UA/NSTEMI, 30 days s/p bare metal stents, 1 year s/p drug eluting stents
CN that controls corneal sensation
V1 branch of trigeminal
coccidioides cutaneous findings
erythema multiforme and erythema nodosum
collagen affected in OI
type I
common association with carpal tunnel syndrome
hypothyroidism
common complication of coronary catheterization
hematoma formation in soft tissues or extension to the retroperitoneal space
common consequence of treated Hodgkin’s lymphoma with chemotherapy and radiation
3.2% develop secondary malignancy
Common extrapulmonary manifestation of mycoplasma pneumonia
Erythema multiforme
common injury after tonic-clonic seizure
posterior dislocation of the shoulder
complete placenta previa management
Cesarean section
Complication of the first two years of menarche
Cycles are irregular, complicated by menorrhagia and are anovulatory
complication of untreated vesicoureteral reflex
UTIs, pyelo, and progressive renal scarring
complications of acute pancreatitis
pleural effusion, ARDS, ileus, and renal failure
Condition characterized by defective mineralization of bone
osteomalacia
Condition characterized by defective mineralization of bone and growth plate cartilage
Rickets
Condition characterized by disordered skeletal remodeling
Paget’s disease of the bone
Conditions other then taponade that have pulses paradoxus
Severe asthma or COPD
confirmatory testing: muscular dystrophy
muscle biopsy, CK for screening
confirmatory tests for SLE
anti-Smith or anti-dsDNA
contraindication to breastfeeding
maternal HIV infection
Cri-du-chat deletion
5p
cyclosporin toxicity
nephrotoxicity, hyperkalemia, HTN, gum hypertrophy, hisutism, and tremor
cystinuria screening
cyanide nitroprusside test
damage that occurs in ethylene glycol poisoning
kidney damage
damage that occurs in methanol poisoning
eye damage
ddx: anterior mediastinum mass
thymoma
ddx: elevated peak pressure with elevate plateau pressure
decreased pulmonary compliance: edema, atelectasis, PNA, or right mainstem intubation
ddx: elevated peak pressure with normal plateau pressure
pathological process causing increased resistance of airways: bronchospasm, mucous plug, biting ET tube
ddx: Howell-Jolly bodies
absence of spleen, splenic infarct, infiltrative d/o of spleen, or splenic congestion
ddx: middle mediastinum mass
bronchogenic cysts, tracheal tumors, pericardial cysts, lymphoma, lymph node enlargement, and aortic aneurysms
DDx: normotensive patients with hypokalemia and metabolic alkalosis
diuretics, vomiting, Bartter synfrom, Gitelman syndrome
ddx: posterior mediastinum mass
meningocele, enteric cysts, lymphomas, diaphragmatic hernias, esophageal tumors, and aortic aneurysms. ALL neurogenic tumors
definitive syphilis dx
dark field microscopy, patients may not have formed antibodies for serologic testing
device to use with pulmonary foreign body
rigid broncoscopy
differentiate types of COPD
chronic bronchitis: normal DLCO, emphysema: decreased DLCO
digoxin toxicity
nausea, vomiting, diarrhea, vision changes, and arrhythmias
DPL indication
hemodynamically unstable with inconclusive FAST examination
drug category: trihexyphenidyl
anticholinergic
drug contraindicated during ACS
dihydropyridine CCBs because the cause peripheral vasodilation and reflex tachycardia leading to worsening ischemia
drug to increase appetite and weight in cancer related anorexia/cachexia
progesterone analogs (megestrol acetate)
drugs that cause folic acid deficiency
phenytoin (impaired absorption), methotrexate, TMP-SMX (antagonize)
drugs that cause interstitial nephritis
cephalosporins, PCN, sulfonamides, NSAIDs, rifampin, phenytoin and allopurinol
drugs that increased the risk of bleeding in those taking warfarin
acetaminophen, NSAIDs, amiodarone, and antibiotics
dx: adult parvo
Anti-B19 IgM
dx: ALL
bone marrow bx
dx: CLL
flow cytometry
DX: developmental dysplasia of the hip
< 6 months: ULS
> 4-6 months: X-ray
…
dx: endometriosis
laparoscopy
dx: esophageal perforation
gastrografin esophography
dx: esophageal rupture
water-soluble contrast esophagram
dx: histoplasmosis
antigen detection in urine or serum
dx: major depressive disorder
5/8 symptoms x 2 weeks, significant functional impairment
dx: melanoma
excisional biopsy
dx: primary hyperaldosteronism
PA:PRA level >30
dx: pyloric stenosis
ULS
dx: SBP
paracentesis with PMN >250 and positive ascites cultures
dx: vasovagal syncope
upright tilt table testing
dx: Zollinger-Ellison syndrome
serum gastrin levels > 1000
dysfunctional uterine bleeding
heavy vaginal bleeding that occurs in absence of structural or organic disease
earliest renal abnormality in diabetes
glomerular hyperfiltration
ECG changes in coarctation
LVH, increased GRS voltage and ST- and T-wave changes
eczema herpeticum
primary HSX associated with atopic dermatitis
electrolyte abnormality in SAH
hyponatremia, cerebral salt wasting syndrome
elevated in CAH 21-hydroxylase deficiency
17-hydroxyprogesterone
elevated in folic acid and cobalamin deficiencies
homocysteine
endocrine disease that causes proximal myopathy
hyperthyroidism
epi: FSGS
AA, obesity, heroin use, and HIV
epi: stress fractures
athletes/nonathletes who increase physical activity, female runners with oligomenorrhea and poor eating habits
factoral study design
randomization into 2 interventions with additional study of 2 or more variables
Familial conjugate hyperbilirubinemia with dark granular pigment in hepatocytes
Dubin-Johnson
features of bacterial sinusitis
sx >10 days, severe sx, fever>39, purulent discharge/face pain, >5 days worsening after improving URI sx
first line agents for HTN in pregnancy
labetalol and methyldopa (ACEi and ARBs teratogenic)
first line therapy for controlling stable angina symptoms
beta-blockers
first line tx HTN in pregnancy
methyldopa, central acting alpha agonist
first renal change in diabetes that can be quantitated
thickening of the glomerular basement membrane
first step in management: suspected congenital diaphragmatic hernia
Placement of orogastric tube
first step in primary amenorrhea evaluation
is there at uterus present
first step in suspected child abuse
full PE
first step in thrombosis of a central line
removal of catheter
Friedrich Ataxia inheritance pattern
AR; trinucleotide repeats
Gaucher’s deficient enzyme
beta-glucosidase
GBS screening in pregnancy
35 to 37 weeks gestation
goal of colposcopy during pregnancy
exclusion of invasive cancer
Gold standard for evaluating cervical incompetence
Transvaginal ultrasound
greatest risk factor for future suicide attempts
past history of suicide attempts
hallmark of prolonged seizures
cortical laminar necrosis
Hallmark ventricular aneurysm EKG findings
Persistent ST elevation after recent MI and deep Q waves in the same leads
hearing tests suggestive of conductive hearing loss
bone conduction>air conduction on Rinne test
height goal by first birthday
50% increase
hemi-neglect lesion
non-dominant parietal lobe
hemophilic arthropathy
iron deposition and synovial thickening with fibrosis
Henoch-Schonelein purpura predisposition
children susceptible to intussusception
Hep E in pregnant women
progression to fulminant hepatitis, especially in 3rd trimester
hereditary spherocytosis pathophys
AD inheritance of abnormal ankryin gene leading to abnormal scaffolding
histoplasma endemic areas
Mississippi and Ohio River Valleys and Central America
how acyclovir causes nephropathy
precipitates in renal tubules causing obstruction and acute renal failure
how dipyridamole works for perfusion scanning
redistribution of blood flow to ‘non-diseased’ segments by inducing coronary steal
how immunizations should be given with pre-term children
given at chronological age, must weigh at least 2 kg before given hep B vaccine
how long to continue antidepressant when treating episode
6 months following the patient’s response
how to differentiate Bartter/Gitleman from diuretics/vomiting
> 20-40 urine Cl
how to differentiate COPD from asthma
bronchodilator response test
how to differentiate emoblic vs. thrombotic limb ischemia
acute onset vs. insidious onset
How to differentiate leukemoid reactions from chronic myeloid leukemia
leukocyte alkaline phosphatse high in leukemoid, low in CML
How to prevent chlamydial conjunctivitis during birth
Maternal prenatal testing, or erythromycin ointment is not effective
how to start opioid pain management
begin with short acting doses, then titrate up to longer acting doses
How trichomonas changes the vaginal milieu
Disrupts normal vaginal pH, increases it between 5-6
Howell - Jolly bodies
Nuclear remnants of red blood cells usually removed by the spleen
Howell-Jolly bodies
nuclear remnants within RBCs, typically removed by the spleen
hypertrophic osteoarthropathy
clubbing and sudden onset of arthropathy in a chronic smoker
hyposthenuria
In sickle cell disease and sickle cell trait, kidneys impaired ability to concentrate urine
imaging: hydatid cysts
eggshell calcification of hepatic cysts on CT
Immunofluorescent findings in bullous phemphigoid
pruritis, tense bullae, urticarial class, IgG and C-3 distributed linearly along the basement membrane zone
important in achalasia workup
endoscopy to r/o esophageal cancer
important management step in androgen insensitivity
gonadectomy after completion of puberty to avoid risk of testicular carcinoma
important screening for cirrhosis dx
endoscopy for varices, ascites prevention, and liver ULS q 6 months for HCC
important tx in CML with Philadelphia chromosome
tyrosine kinase inhibitor
increased risk of seborrheic dermatitis
Parkinson’s and HIV
increased risk with RA
osteopenia and osteoporosis
indicated before trastuzumab initiation
echocardiogram because risk of cardiotoxicity, especially in those with low EF
indicates poor prognosis in CLL
thromnocytopenia
Indication for steroids in PCP
PaO2 < 70, A-a gradient > 35
indication: metformin in PCOS
impaired glucose tolerance
Indication: pica especially for ice
Iron deficiency anemia
Indications for aortic valve replacement
Symptomatic; severe AS undergoing CABG or other valvular surgery; poor LV systolic function or hypertrophy
indications for bladder/renal ULS in children
<24 months with febrile UTI, recurrent UTI, fmhx of urological disease, HTN, poor growth, lack of response to appropriate tx
indications for carotid endarterectomy
symptomatic 70-99% occlusions, asymptomatic 60-99%
indications for endometrial biopsy in endometrial bleeding
> 35, HTN, diabetes or obesity present
indications for endoscopy for dyspepsia
> 55 with alarm symptoms: weight loss, dysphagia, or persistent vomiting
indications for external cephalic version
> 37 weeks, no contraindications to vaginal delivery and fetal well being established
indications for GBS ppx in unknown status
18 hours, GBS bacteruria during pregnancy, hx prior GBS sepsis baby
indications for hospitalization for anorexia nervosa
dehydration, electrolyte disturbance, bradycardia, severe weight loss
indications for parathyroidectomy in asymptomatic hyperparathyroid patients
Ca>1mg upper limit of normal, <T-2.5, reduced renal function
initial manifestation of hypocalcemia
hyperactive DTRs
Innervation: common peroneal nerve
Muscles of the interior and lateral leg; sensation to anterolateral leg and dorsum foot
Innervation: for moral nerve
Anterior compartment of the thigh, responsible for knee extension and hip flexion
Innervation: obturator nerve
New York compartment of the thigh; controlled abduction of the thigh; sensation over the medial side
Innervation: tibial nerve
Posterior compartment of the thigh and leg; flexion of the knee and digits, and plantar flexion of the foot
instructions for laryngomalacia
hold child upright for 1/2 hour after feeding, never feed lying down
instructions for sildenafil when patient on alpha blocker
given with at least 4 hour interval to reduce risk of hypotension
iron overload infection predispostion
listeria and yersinia enterolitica
JAK2 mutation association
PCV
Jones criteria for rheumatic fever
major- carditis, migratory polyarthritis, Sydenham chorea, subcutaneous nodules and erythema marginatum