STD drugs 12/17

Question 1

gonorrhea

Answer 1

ceftriaxone+azithromycin or doxycycline for chlamydia

AE ceftriaxone:C-Dif

Question 2

syphilis

Answer 2

PCN G

Question 3

Jarisch-Herxheime reaction

Answer 3

acute febrile rx with headache and myalgia that occurs within 24 hours after tx.

may induce early labor or cause fetal distress in pregnant women

Question 4

trichomoniasis

Answer 4

metronidazole or tinidazole

members of nitroimidazole, nitro group is reduced in anaerobic bacteria–> reactive products–> antimicrobial activity

pt should abstain from EtOH

Question 5

bacterial vaginosis

Answer 5

metronidazole PO or metronidazole gel or clindamycin cream

clindamycin cream not recommended for pregnant women

Question 6

PID (parental)

Answer 6

cefotetan or cefoxitin+doxycycline

cefoxitine and cefotetan are 2 generation cephalosporins(cephamycin).used for surgical prophylaxis in abd surgery and abd and pelvic infx

AE:thrombophlebitis after IV

methylthiotetrazole group–> disulfiram like rx with EtOH.Can also inhibit vit.K and prolong bleeding

Question 7

PID (oral)

Answer 7

levofloxacin or ofloxacin with or without metronidazole

AE:GI upset,photosens,headache

prolong QT,arthralgia and tendon rupture

Question 8

herpes

Answer 8

acyclovir