- Staphylococcus Aureus: (also covers Streptococcus); Streptococcus specific

Question 1

Staph Sensitive (MSSA): IV

Answer 1

Oxacillin/nafcillin, or cefazolin (first-generation cephalosporin)

Question 2

Staph Sensitive (MSSA): Oral

Answer 2

Dicloxacillin, or cephalexin (first-generation cephalosporin)

Question 3

Resistant Staph (MRSA): Severe Infection

Answer 3

Vancomycin, Linezolid (s/e: thrombocytopenia), Daptomycin (myopathy, increased CPK), Ceftaroline, tigecycline, or telavancin.

Question 4

Resistant Staph (MRSA): Minor Infection

Answer 4

Trimethoprim/Sulfamethoxazole, clindamycin, doxycycline

Question 5

Penicillin Allergy (staph): Rash, Anaphylaxis, Severe, Minor infection

Answer 5

Rash: Cephalosporins; Anaphylaxis: Macrolides (azithromycin, clarithromycin), or clindamycin; Severe infection: Vancomycin, Linezolid, Daptomycin, Telavancin;
Minor infection: Macrolides (azithromycin, clarithromycin), clindamycin, TMP/SMX

Question 6

Streptococcus specific

Answer 6

Penicillin, Ampicillin, Amoxicillin