Stan's MCQ session

Question 1

What EEG signal do you get when sevo MAC >2

Answer 1

isoelectric, more so than burst suppression

Question 2

What effect site concentration would you get in a 70kg man with 200mg propofol?

Answer 2

around 8 microg/ml

This is on a Marsh model

Question 3

What kind of anaemia is associated with prolonged vomiting

Answer 3

Microcytic anaemia due to lack of iron absorption

Question 4

How does B agonist cause bronchodilation

Answer 4

Gs GPCR -> increase cAMP -> inhibits MLCK -> prevents contraction

Question 5

What is the conversion from mmHg to cmH2O

Answer 5

divide by 0.74

Question 6

What is the metabolic role of growth hormone

Answer 6

Growth - utilisation of glucose, so it stimulates gluconeogenesis

Question 7

Bioavailability of

• Codeine
• Tramadol
• Oxycodone
• Tapentadol

Answer 7

50%
85%
50%
10%

Question 8

Does carboxy-Hb cause a left or right shift on ODC

Answer 8

left shift

Positive cooperatively - as Hb binds to O2, it wants to bind more O2.

As carbon monoxide binds to the site, it increases the affinity to O2.

Question 9

What is the function of ANP on the renal glomerulus

Answer 9

Decreased afferent arteriole resistance
Increased renal blood flow
increased GFR
slight reduction in filtration fraction

Question 10

How is naloxone different to morphine?

Answer 10

Alkyl substitution at N17 to confer antagonism

Question 11

Why does zero-ing the art line do?

Answer 11

Pressure measurement is relative to atmospheric pressure. Zeroing is referencing against atm.

Position does not matter as atm pressure is the same

Question 12

The use of sodium nitroprusside (T/F)

• Results in increase in plasma renin activity
• Reduces cerebral metabolic rate of oxygen
• Cyanocobalamin can be used to prevent or treat SNP toxicity
• Thiocyanate can be used to treat cyanide toxicity associated with SNP

Answer 12

T
F
F
F

Vasodilation, reduce renal perfusion, increase renin
Cyanocobalamin always has cyanide in it. It is the synthetic
- Hydroxycobalamin is the one to treat cyanide toxicity
- Thiosulfate is used to treat cyanide toxicity

Question 13

Describe the action of dipyridamole?

Answer 13

Used in asasantin (with aspirin)
Anti-platelet drug

Can cause bronchoconstriction and hypotension.

Question 14

In a healthy adult, what is the minimum urine volume required to extreme 600mOsm of solute?

Answer 14

500ml

Question 15

What is MET of 10 in 50kg woman?

Answer 15

10 MET = 10x 3.5ml x kg x min

= 35 x 50 = 1750ml/min

Question 16

What is the end point of using hypertonic saline?

Answer 16

Na of 155 mmol/L or ICP < 20 mmHg

Question 17

What is reflection coefficient?

Answer 17

How much of the substance stays in the vascular space.

Mannitol - 0.9
Hypertonic saline - very close to 1

Question 18

What is heterometric auto regulation of the heart describes?

Answer 18

Increase in the force of contraction occurs in response to increased preload.

Question 19

T/F Femoral nerve

• Lies within the femoral sheath
• Branch supplies part of the foot
• Shares its origin with obturator nerve
• Lies medial to the femoral artery

Answer 19

F - outside of the sheath
T - Saphanous branch
T - Femoral nerve L2,3,4, same as obturator nerve.
F - lies lateral to femoral artery

Question 20

What accounts for the variability in response with heparin?

Answer 20

Variable antithrombin III levels

Question 21

What is the metabolic pathway of heparin and which one is saturable

Answer 21

reticuloendothelial system is saturable

Heparinase system, which is not saturable

Question 22

Why would atropine reduce stroke volume?

Answer 22

venous return unchanged, heart rate increases, stroke volume decreases due to reduced diastolic filling time.