Stages of tissue repair Flashcards
Inflammation
- Heat (local) - Calor
- Redness - Rubor
- Swelling - Tumor
- Pain - Dolar
- Loss of function - functio laesa
protective mechanism to rid the body of an irritant and promote repair and healing of damaged tissues
Phases of inflammation-
- Acute Inflammatory Phase: Few hours - 3 days
- Repair Phase: 24 hours - 6 weeks
- Remodeling Phase: 2 weeks to 12 months
Acute Inflammatory Phase: Few hours - 3 days
- defend against foreign substance and infection, dispose of dead or dying tissue, immobilize injured area, compartmentalize area of damage
1. Initial vasoconstriction (30 sec; reflexive) (NEpi, serotonin)
2. Gradual vasodilation (causes bleeding to start–>histamines, prostaglanines)
cells: Mast cells, leukocytes
Repair Phase: 24 hours - 6 weeks
- Deposition of Collagen
- Macrophages
- Granulation tissue - form gel like matrix of collagen, hyaluronic acid and fibronectin. scar!
- Fibroplasia - hours after injury
- Wound contraction
Remodeling Phase: 2 weeks to 12 months
a.During phase 2 collagen is laid down at random (Type III); remodeling to type I to increase tensile strength
Window of 8-10 weeks where collagen can be remodeled
80% as strong as original non-injured tissue
Factors that delay tissue healing -
Intrinsic factors
Extrinsinc factors
Iatrogenic
Soft Tissue Healing Potential -
- Cartilage: limited potential; poor vascular supply
- Ligaments: slower to heal; 1 year
- Skeletal mm: heals with a collagen scar at the same rate of other vascular tissues
- Nerve: peripheral nerves: fair, CNS: poor
Acute Inflammatory Phase: Few hours - 3 days CHEMICALS
chemicals:Serotonin - vasoconstrictor
Heparin - temporary blood coagulation
Histamine - first chemical, strong vasodilator, increases permeability
Bradykinins - increase permeability and pain with PG
PG - released from phospholipids; ARA
