Stages of Healing Ch.1 Flashcards
What are the 4 stages of healing?
- ) Hemostasis
- ) Inflammatory
- ) Proliferation (repair)
- ) Remodeling/maturation
Hemostasis involves what and lasts how long?
Initial blood clotting to stop bleeding. Lasts seconds -> minutes.
What is another name for the inflammatory stage, and how long does it last?
The acute phase.
Hours -> days -> weeks
How long is the proliferation phase?
Weeks -> months
How long is the maturation phase?
Months -> year
Does the cause of injury change the stages of the healing process? Are there any exceptions?
No. Time can vary
Are the stages of healing clearly demarcated and occur separately?
No, there is much overlap.
What is the purpose of the Inflammation (acute) phase?
To defend against foreign intruders (infection), Remove damaged tissue and debris, Immobilize area.
How well will avascular or poorly vascularized tissue heal?
Not well
What are the signs of Inflammation?
Rubor - redness Calor - heat Dolor - pain Tumor - swelling Functio laesa - loss of function
What characterizes the inflammation stage at the site of injury?
Vasodilation, Increased capillary permeability, Phagocytosis by neutrophils and macrophages.
Which inflammatory chemicals cause pain?
Bradykinin, prostaglandins, serotonin
Inflammation can cause secondary injury. What are the 2 types of secondary injury?
Secondary enzymatic injury, secondary hypoxic injury.
What characterizes secondary enzymatic injury?
Lysosomal enzymes released
Not specific
Healthy tissue is damaged
What characterizes secondary hypoxic injury?
Hemorrhage, edema, clotting, spasm, hematoma.
These lead to decreased O2 and nutrients.
Damage to surrounding uninjured tissue.