Stability 2

Question 1

what are chemical incompatibilitesi

Answer 1

Excipients can induce degradation of either the active ingredient OR another excipient.

• EX
  
  • Transesterification of methylparaben and sorbitol to form a mixture of esters
  • transesterification of aspirin with phenylephrine HCl, acetaminophen, or PEG
    
    • aspirin reacts with PEG in suppositories so wil always be in fatty base
      
      • will make an ester
  • lactose and amine drugs undergo maillard rxn forming glycosyl amine -> rearranges to a sugar

Question 2

KINETICS LOOK AT NOTES