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125: Pharmaceutics II > Excipients: tablets > Flashcards

Excipients: tablets Flashcards

1
Q

group 1 vs group 2 excpients for tablet preparation

A
  • Group 1
    • helps w/ processing and compression characteristics
    • diluants, binders, glidants and lubricants
  • Group 2
    • help give disirable physical character to finished tab
      • disintegrants, surfactants, flours, flavours, swetening agents, polymers
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2
Q

what is the purpose of diluent

A

increase bulk of tablet

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3
Q

lactose

A

filler/diluent

-anhydrous: spray dried for direct compression

Monohydrate: for wet granulation

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4
Q

microcrystalline cellulose

A

dilutent, disintegrant, binder

used in direct compression if particles are 100 um, and in granulations if particules are 50 um

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5
Q

Dicalcium phosphate dihydrate

A

diluent

Excellent flow properties, brittle material

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6
Q

Calcium carbonate Sodium carbonate

A

diluent

brittle

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7
Q

Starch

A

diluent, binder or disintegrant

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8
Q

Dextrose, Sucrose, Mannitol, Sorbitol

A

filler and sweetener used in effervescent and chewable tablets

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9
Q

what is the most common binder

A

starch mucilage

*Solution binders: added as the granulation fluid, more effective and most common

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10
Q

what are common solution binders

A

starch mucilage

polyvinylpyrrolidone

gelatin

cellulose derivates (methylcellulose, hydroxypropyl methylcellulose)

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11
Q

what are dry binders for for tablet making

A

*added before wet granulation

Microcrystalline cellulose (used as binder and diluent)

polyvinylpyrrolidone (PVP)

pregelatinized starch

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12
Q

starch mucilage

A

solution binder

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13
Q

sucore solution

A

solution binder

*prob also sweetener

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14
Q

Polyvinylpyrrolidone

A

solution and dry binder

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15
Q

gelatin

A

solution binder

used to make shell (hard and sfot gel)

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16
Q

Microcrystalline cellulose

A

dry binder

diluent

disintegrant

sorbent

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17
Q

starch glyolate

A

disintegrant

swells on contact with water (super disintegrant)

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18
Q

Croscarmellose sodium

A

disintegrant

swells on contact w/ water (super disintegrant)

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19
Q

Crospovidone

A

super disintegrants

swells on contact w/ water

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20
Q

Organic acid (citric acid + tartaric ) + sodium bicarbonate

A

used in effervesent tabs (disintegrant)

1 : 2 : 3.4

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21
Q

iron oxide

A

colouring agent

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22
Q

indigo carmine

A

colouring agent

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23
Q

sodium lauryl sulfate

A

wetting/solbilubilizing agent

also processing agent for capsules: makes gelatin uniformly cover mold

soluble lubricant

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24
Q

magnesium stearate

A

insoluble lubricant

also antiadherant for capsule manufacture

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25
Q

calcium stearate

A

insoluble lubricant

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26
Q

stearic acid

A

insoluble lubricant

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27
Q

light mineral oil

A

insoluble lubricant

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28
Q

sodium benzoate

A

soluble lubricant

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29
Q

PEG 4000 and 6000

A

soluble lubricant

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30
Q

colloidal silicon doixide

A

glidant

*helps flow by dec interparticle friction

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31
Q

silicon doxide

A

viscoity enhancer

*used in rectal doseage forms

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32
Q

talc

A

glidant

*helps flow by dec interparticle friction

also antiadherant for capsule manufacture

33
Q

calcium silicate

A

glidant

*helps flow by dec interparticle friction

34
Q

magnesium carboante

A

glidant *helps flow by dec interparticle friction

sorbant * Sorbs oil or oil-drug solutions into powder mixture

35
Q

docusate sodium

A

wetting/solubliizing agent

*Facilitates solubilization of water-insoluble drugs, wetting of hydrophobic tablets

36
Q

lecithin

A

wetting/solubliizing agent

*Facilitates solubilization of water-insoluble drugs, wetting of hydrophobic tablets

37
Q

poloxamer

A

wetting/solubliizing agent

*Facilitates solubilization of water-insoluble drugs, wetting of hydrophobic tablets

38
Q

polysorbate 80

A

wetting/solubliizing agent

*Facilitates solubilization of water-insoluble drugs, wetting of hydrophobic tablets

40
Q

fumed silica

A

sorbent

sorbs oil or oil-drug solutions into powder mix

41
Q

kaolin

A

sorbent

sorbs oil or oil-drug solutions into powder mix

42
Q

hypromellose

A

shell for capsules

*plant based option

43
Q

Hydroxypropyl methylcellulose (HPMC)

A

shell for capsules

*plant based

44
Q

pullulan

A

polysaccharide for capsule shell

45
Q

paraben

A

persevative

46
Q

propylene glycol

A

plasticizer

47
Q

cetyl alcohol

A

plasticizer

48
Q

surfactants

A

solubilizing agents

49
Q

butylated hydroxytoluene

A

antioxidants

uned in rectal/vag dosage forms

50
Q

what can be used in sealling step in sugar coating

A

Shellac

Cellulose acetate phthalate (CAP)

Polyvinyl acetate phthalate (PVAP)

51
Q

Cellulose acetate phthalate (CAP)

A

used in sealing step in sugar coating

used in coating for delayed release polymer

52
Q

Polyvinyl acetate phthalate (PVAP)

A

used in sealing step in sugar coating

used in for delayed release polymer

53
Q

shellac

A

used for sealing of sugar coating but also delayed relase polymer

54
Q

titanium dixoide

A

used for colouring

also can be sued at 1% as an opacifier

55
Q

what is used for immeidate release coating

A
  • cellulose derivates
    • hypromellose
    • hydroxypropyl cellulose
  • vinyl derivates
    • polyvinyl alc
  • acyrlic acid derivates
    • methylmethacrylate copolymer
    • methacrylic acid
56
Q

Hypromellose

A

used for IR coating

57
Q

hydroxypropyl cellulose

A

used for IR coating

58
Q

polyvinyl alcohol

A

used in IR coating

*vinyl derivates

59
Q

Methylmethacrylate copolymer

A

acrylic acid derivative for IR coating

60
Q

Methacrylic acid

A

acylic acid derivate for IR coating

61
Q

HPMCAS

HPMCP

A

used in delayed replease coating

62
Q

**poly(methylacrylic acid): ethyl acrylate (1:1)

A

used in dealyed released coating

idk she had this ** in the ntoes

63
Q

rosin

A

used in DR coating

64
Q

ehtylcellulose

A

extended release coating

Forms water permeable membrane for dissolution of drug

65
Q

ammonio methacrylate copolymer type A and B

A

extended realse coating

66
Q

polyvinyl acetate

*when it is polyvinyl acetate phthalate its used for other coatings

67
Q

glycerin

A

plasticizer

used in soft shell caps

68
Q

polyethylene glycol

A

plasticizer

69
Q

propylyene glycol

A

plasticizer

70
Q

diethyl phthalate

A

plasticizer

71
Q

dibutyl sebacate

A

plastiizier

72
Q

triethyl citrate

A

placticizer

73
Q

tributyl citrate

74
Q

triacetin

A

plasticizer

75
Q

Glyceryl monostearate

A

anti adherant

76
Q

high ME PEGS

A

anti adherants

77
Q

Sorbitan monooleate

A

surfactiant

78
Q

Sodium dodecyl sulfate

A

surfactant

79
Q

simethicone

A

anti-foaming

125: Pharmaceutics II (5 decks)

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