St. John's Wort

Question 1

used

Answer 1

to treat depression

Question 2

mechanism

Answer 2

thought to selectively inhibit the reuptake of serotonin

Question 3

adverse effects

Answer 3

photosensitivity (stinging of hands)

Question 4

drug interactions

Answer 4

induction of cytochrome P450 enzymes
intensification of serotonin effects if taken w/ other antidepressants
interacts w/ warfarin, digoxin, oral contraceptives
increases analgesic effect of morphine