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Pharm 835 > SSTI > Flashcards

SSTI Flashcards

1
Q

Uncomplicated SSTIs

A
  • Superficial infections
    ex. cellulitis, impetiginous lesions, furuncles, simple abscesses
  • Treatment usually requires abx and/or simple incision and drainage
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2
Q

Complicated SSTIs

A
  • Deep soft tissue infections
    ex. infected burns, ulcers, major abscesses
  • May require surgical interventions
  • Significant underlying disease state which complicates response to treatment
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3
Q

Main pathogens in SSTIs

A
  • Staph aureus (puss)

- Strep pyogenes (red/hot)

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4
Q

Indications for abx use in abscesse management

A
  • Systemic signs of infection
  • Cellulitis or phlegmon
  • Immunocompromised
  • Certain foreign bodies
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5
Q

Cellulitis

A
  • Group A strep
  • S. aureus
  • Swelling, redness, edema, pain, non-elevated, poorly defined
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6
Q

Treatment of mild purulent SSTIs

A
  • Simple incision and drainage
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7
Q

Empiric treatment of moderate purulent SSTIs

A

-Bactrim
or
-Doxycycline

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8
Q

MRSA treatment of moderate purulent SSTIs

A

-Bactrim

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9
Q

MSSA treatment of moderate purulent SSTIs

A

-Dicloxacillin
or
-Cephalexin

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10
Q

Empiric treatment of severe purulent SSTIs

A
  • Vancomycin
  • Daptomycin
  • Linezolid
  • Ceftaroline
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11
Q

MRSA treatment of severe purulent SSTIs

A
  • -Vancomycin
  • Daptomycin
  • Linezolid
  • Ceftaroline
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12
Q

MSSA treatment of severe purulent SSTIs

A
  • Nafcillin
  • Cefazolin
  • Clindamycin
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13
Q

Treatment of mild non-purulent SSTIs

A

Oral

  • Penicillin VK
  • Cephalosporin
  • Dicloxacillin
  • Clindamycin
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14
Q

Treatment of moderate non-purulent SSTIs

A

Intravenous

  • Penicillin
  • Ceftriaxone
  • Cefazolin
  • Clindamycin
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15
Q

Treatment of severe non-purulent SSTIs

A

Intravenous
-Vancomycin
Plus
-Zosyn

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16
Q

Treatment of defined necrotizing infection with strep pyogens

A

-Penicillin + Clindamycin
or
-Doxycycline plus Ceftazidime/Ciprofloxacin

17
Q

Erysipelas patho

A
  • Most commonly group A strep

- infants, young children, elderly, nephrotic syndrome

18
Q

Erysipelas treatment

A

-Mild to moderate non-purulent SSTI
-Penicillin
-Ceftriaxone
-Cefazolin
-Clindamycin
IV or PO depending of the setting

19
Q

Impetigo patho

A
  • Group A strep (no bullous)
  • Staph aureus (bullous)
  • More common in children
20
Q

Impetigo treatment

A 
-< 10 lesions = topical mupirocin 
>10 lesions 
Bactrim 
or 
Doxycycline
21
Q

Necrotizing fasciitis patho

A

Most common bugs

  • Group A strep
  • S. aureus
  • Clostridium sp.
22
Q

Treatment of necrotizing fasciitis

A 
-PCN G + clindamycin 
add 
-Vancomycin if MRSA is suspected 
Polymicrobial?
Treat with 
-Vanco + Zosyn + Imipenem
23
Q

Diabetic foot infections (DFI) patho

A
  • S. aureus is the most common pathogen

- gram positive aerobes ^^

24
Q

Treatment of DFI

A
  • Local wound care
  • Immobilization
  • Drainage
  • Abx (2 weeks, 6 weeks if osteomyelitis)
  • Amputation (last resort)
25
Q

Classifications of DFI

A

-1 = uninfected
-2 = mild infection
-3 = moderate infection
-4 = severe infection
1+2 = not limb threatening
3 = possibly limb threatening
4 = limb threatening

26
Q

Mild DFI MSSA (strep spp)

A

All are appropriate monotherapy options

  • Dicloxacillin
  • Clindamycin
  • Cephalexin
  • Levofloxacin
  • Augmentin
27
Q

Mild DFI MRSA

A

-Doxycycline
or
-Bactrim

28
Q

Moderate to Severe DFI MSSA

A
  • Levofloxacin
  • Moxifloxacin
  • Cefoxitin
  • Ceftriaxone
  • Unasyn
  • Ertapenem
  • Clindamycin + cipro/levo
  • Imipenem-cilastatin
29
Q

Moderate to Severe DFI MRSA

A
  • Linezolid
  • Daptomycin
  • Vancomycin
30
Q

Moderate to severe DFI P. aeruginosa

A

-Zosyn

31
Q

Moderate to sever MRSA DFI Enterobacteriacae, Pseudomonas, and obligate anaerobes

A 
-Vanco 
Plus one of the following 
-Zosyn
-Ceftazidime
-Cefepime
-Carbapenem
32
Q

Dog bite most common pathogen

A

-Pasteurella canis

33
Q

Dog bit treatment

A
  • Augmentin bid

- Duration 10 to 14 days

34
Q

Cat bite most common pathogen

A

-Pasteurella multocida

35
Q

Cat bite treatment

A
  • Augmentin

- Duration 10 to 14 days

36
Q

Human bite patho

A
  • Polymicrobial

- Ya NASTY

37
Q

Human bite “early” treatment

A
  • Augmenting

- Duration 5 days

38
Q

Human bite “late” treatment

A
  • Unasyn
  • Cefoxitin
  • Zosyn
  • Clindamycin + cipro or bactrim (10mg/kg/day)

Pharm 835 (7 decks)

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