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Pharmacology Test 3 > SSRIs > Flashcards

SSRIs Flashcards

1
Q

fluoxetine: class

A
  • SSRI
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2
Q

difference b/w TCAs and SSRIs

A
  • SSRIs are equally effective, better tolerated, and safer
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3
Q

fluoxetine: indications

A
  • major depressions
  • OCD
  • panic disorder
  • PMDD
  • bulimia nervosa
  • unlabeled: PTSD, social phobia, alcoholism, ADHD, micgraine, tourette’s
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4
Q

fluoxetine: MOA

A
  • SSRIs selectively block neuronal reuptake of serotonin (5HT)
    • so the conc of 5HT in the synapse inc and causes inc activation of 5HT receptors
  • relief of depression takes several weeks to fully develop even though receptors blocked w/in hours
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5
Q

fluoxetine: SE

A
  • sexual dysfunction: impotence, delayed/absent orgasm, delayed/absent ejaculation, dec sexual interest)
  • rash
  • nausea
  • headache
  • weight gain
  • CNS effects: drowsiness, insomnia, anxiety
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6
Q

fluoxetine: ADRs

A
  • neuroleptic malignant syndrome
  • seizures
  • suicidal thoughts
  • Torsades de Pointes
  • serotonin syndrome
  • neonatal effects:
    • neonatal abstinence syndrome
    • persistent pulmonary HTN of the newborn (PPHN)
    • VSD
  • GI bleed
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7
Q

what is serotonin syndrome?

A
  • starts 2-72 hours after taking an SSRI
  • S/S:
    • altered mental status
    • incoordination
    • myoclonus
    • hyperreflexia
    • excessive sweating
    • tremor
    • fever
  • may cause death
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8
Q

what is neonatal abstinence syndrome?

A
  • withdrawal syndrome in newborn
  • S/S: irritability, abnormal crying, tremor, respiratory distress, seizures
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9
Q

what is PPHN?

A
  • persistent pulmonary HTN of the newborn
  • risk of death
  • among survivors: cognitive delay, hearing loss, neurologic abnormalities
  • tx: ventilation, O2 and NO, IV sodium bicarb
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10
Q

SSRIs: nursing implications

A
  • contraindicated: pts taking MAOIs
  • caution in pregnant patients and older adults
  • make sure to take meds as prescribed even if feel cured
    • should continue 4-9 mos
  • usually take 1-3 weeks for effects to develop
  • administer in the morning to minimize sleep problems
  • take with food to minimize GI upset
  • do not d/c abruptly
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11
Q

paroxetine: class

A
  • SSRI
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12
Q

paroxetine: indcations

A
  • major depression
  • OCD
  • panic disorder
  • social phobia
  • GAD
  • PTSD
  • PMDD
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13
Q
  • paroxetine: MOA
A
  • SSRIs selectively block neuronal reuptake of serotonin (5HT)
    • so the conc of 5HT in the synapse inc and causes inc activation of 5HT receptors
  • relief of depression takes several weeks to fully develop even though receptors blocked w/in hours
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14
Q

paroxetine: SE

A
  • nausea
  • somnolence
  • sweating
  • tremor
  • fatigue
  • headache
  • weight gain
  • sexual dysfunction
  • CNS stimulation: insomnia, inc waking
  • antimuscarinic effects
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15
Q

paroxetine: ADRs

A
  • neuroleptic malignant syndrome
  • seizures
  • suicidal thoughts
  • Torsades de Pointes
  • serotonin syndrome
  • neonatal effects:
    • neonatal abstinence syndrome
    • persistent pulmonary HTN of the newborn (PPHN)
    • VSD
  • GI bleed
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16
Q

sertraline: class

A
  • SSRI
17
Q

sertraline: indications

A
  • major depression
  • OCD
  • panid disorder
  • social phobia
  • PTSD
  • PMDD
  • off label: GAD
18
Q

sertraline: MOA

A
  • SSRIs selectively block neuronal reuptake of serotonin (5HT)
    • so the conc of 5HT in the synapse inc and causes inc activation of 5HT receptors
  • relief of depression takes several weeks to fully develop even though receptors blocked w/in hours
19
Q

sertraline: SE

A
  • headache
  • CNS stimulation: insomnia, agitation, nausea, diarrhea, tremor
  • weight gain
  • sexual dysfunction
20
Q

sertraline: ADRs

A
  • neuroleptic malignant syndrome
  • seizures
  • suicidal thoughts
  • Torsades de Pointes
  • serotonin syndrome
  • neonatal effects:
    • neonatal abstinence syndrome
    • persistent pulmonary HTN of the newborn (PPHN)
    • VSD
  • GI bleed

Pharmacology Test 3 (10 decks)

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