SSRI - Citalopram Flashcards
1
Q
What does SSRI stand for?
A
selective serotonin reuptake inhibitors
2
Q
What are SSRIs such as citalpram used for?
A
1) first line for moderate to severe depression
2) Panic disorder
3) Obsessive compulsive disorder
3
Q
What is the mechanism of SSRIs (Citalopram)
A
- preferentially inhibit neuronal reuptake of serotonin from synaptic cleft so increases its availability for neurotransmission.
4
Q
How do SSRIs differ from tricyclic antidepressants?
A
SSRIs
- do not inhibit noradrenaline uptake
- causes less blockade of other receptors.
5
Q
Why are SSRIs prefered over tricyclic antidepressants for the treatment of depression?
A
- less side effects
- less dangerous in overdose
6
Q
What are the side effects of SSRIs ?
A
- GI upset
- appetite / weight disturbance
- hypersensitivity
- HYPONatraemia
- suicidal thoughts/ behaviour
- lower siezure threshold
- prlonged QT interval –> arrhythmias
- increased risk of bleeding
- serotonin syndrome at high dosease
7
Q
What are the side effects of sudden withdrawal of SSRIs?
A
- GI upset
- neuro
- flu symptoms
- sleep disturbance
8
Q
What are the contraindication of SSRIs?
A
- epilepsy
- peptic ulcer
- young people
- hepatic impairment
9
Q
What are the drug interactions of SSRIs?
A
- monoamine oxidase inhibitors
- drugs that prolon QT interval e.g.
- antipsychotics
- quinines
- quinolones
- macrolides
10
Q
When should gastroprotection be given with SSRIs?
A
with aspirin and NSAIDs
11
Q
What is the starting dose of citalopram?
A
20mg orally daily
