Splinting and Fractures Flashcards
Osteoblasts
Derived from mesenchymal cells
Produce osteocalcin
Needs 1,25-Dihydroxyvitamin D
Produce Type I collagen
Osteoblasts are effected by?
Interleukins
Platelet derived growth factor
Insulin derived growth factor
Receptors for osteoblasts
Estrogen Prostaglandins Glucocorticoids 1,25 vitamin D PTH
Osteoclast stimulated by?
stim by calcitonin and inhibited by PTH
Multinucleated Giant cells
collagen
90% of organic matrix
Tensile strength
Prosteoglycans
Inhibit mineralization
Partially responsible for compressive strength
3 Non-Collagenous proteins
Osteocalcin
Osteonectin
Osteopontin
Bone Matrix (inorganic)
Calcium Hydroxyapatite
Responsible for compressive strength
Osteocalcium Phosphate
Brushite
Cortical bone (Lamellar)
80% of skeleton
Haversian canals – nutrient supply
Stress oriented formation
Cancellous bone (Lamellar)
Trabecular (spongy)
Higher rate of remodeling
Immature (Woven)
Not stress oriented
Elastic in nature
Embryonic skeleton
Fracture healing
Pathologic (Woven)
Random organization
Weak
Tumors
Inflammatory response
Bleeding to area of insult
Hematoma – fibrin clot, growth factors
repair of fracture
Primary callous @ 2 wks
Bridging occurs
Assisted by medullary callous
remodeling of fracture
Initiates during repair
Complete when repopulation of marrow space