Splenomegaly

Question 1

Causes of isolated splenomegaly

Answer 1

Lymphoproliferative disorder (but usually includes also lymphadenopathy and hepatomegaly)
(Massive in CML/myelofibrosis, less so in CLL, lymphoma, cirrhosis, EBV, CMV and SBE)

Chronic malaria

Kala-azar (visceral leishmaniasis)

Schistosomiasis

Question 2

Uncommon causes

Answer 2

Feltys syndrome
Chronic haemolytic anaemia
Infective endocarditis
Left sided portal hypertension (portal or splenic vein thrombosis (consider pancreatic mass)