Splenomegaly

Question 1

A reticuloendothelial organ

Answer 1

spleen

Question 2

Embryonuc origin

Answer 2

At 5th week of gestation in dorsal mesogastrium
Migrated to LUQ,
attatches to stomach via gastrolineal ligament and to kidney via lineorenal ligament

Question 3

Accessory spleen develops if

Answer 3

Hillocks fail to unify

Question 4

Physiological function of spleen

Answer 4

Sequestration of defective rbc
Synthesis of antibody in white pulp
Remove antibody coated bacteria and antibody coated blood cell from circulat

Question 5

Spleen composed of

Answer 5

Red pulp and white pulp
Which are malphigus term for red blood filled sinuses and reticuloendothelial cell lined cords and white lymphoid follicles arrayed within red matriX

Question 6

Spleen

Answer 6

Is in portal circulation

Question 7

Blood flow in spleen

Answer 7

150 ml/min through splenic artery finally ramifies into central arterioles

Question 8

Fate of blood entering splenic circulation

Answer 8

Majority of blood from central arterioles flow to macrophage filled sinus and cords and capillaries-veins

Blood entering sinuses reenter circulation via splenic venules

Entering cords…undergo a inspection..to enter the circulation blood in the cords should squeeze through slits in the cord lining to enter sinuses that lead to venuels

Question 9

What happend to old rbc in cords?

Answer 9

Old and damaged erythrocytes are less deformable so they are retained in the cords , where they are destroyed and compartments are recycled

Question 10

Pitting

Answer 10

Process of passing through slits

Pitting can remove red cell inclusion bodies such as parasites, nuclear residua, howell jollybodies, denatured hemoglobin(heinz bodies

Question 11

Y pitting and culling should go simultaneouly

Answer 11

It should occur without significant delay bcoz blood transit time in spleen is slightly lower than in other organs

Question 12

Spleen assist in

Answer 12

Help host in adapting to hostile environment
Clearamce of bacteria and particulated from blood

Generation of immune response to certain pathogens

Generation of cellular components of blood under circumstances in which bone marrow is unable to meet the needs

Question 13

Extramedullary hematopoesis

Answer 13

The spleen help in production of components of blood when bone marrow is unableto meet the needs

Question 14

Spleen

Answer 14

some animals can store rbc in spleen
Not in humans
In humans one third of platelets and marginated nuetrophils are present