Specific drugs Flashcards
SSRIs.
Fluoxetine.
Sertraline.
Citalopram.
TCAs.
Amitriptyline.
Amoxapine.
First line medication in depression.
SSRI – sertraline.
First line medication in anxiety disorders.
SSRI – sertraline.
First generation anti-psychotics.
Haloperidol.
Chlorpromazine.
Second generation anti-psychotics.
Aripiprazole.
Olanzapine.
Risperidone.
Clozapine.
Important side effect of risperidone.
Reduced libido.
Useful feature of aripiprazole.
Good choice in patients who are concerned about weight gain.
Clozapine monitoring.
Weekly FBC for 18 weeks, then fortnightly till one year, then monthly.
Affected by smoking.
Antipsychotic side effects.
Sedation. EPSE. Hyperprolactinaemia. Reduced seizure threshold. Metabolic syndrome. Anti-cholinergic SE. Postural hypotension.
Acute bipolar medications.
Benzodiazepines – diazepam.
Antipsychotics – quetiapine.
Long-term bipolar medications.
Mood stabilisers: Carbamazepine. Lithium. Valproate. Lamotrigine.
Hypnotics.
Benzodiazepines – diazepam.
Z drugs – zopiclone.
Anxiolytics.
Benzodiazepines – diazepam, lorazepam.
Other – buspirone, pregabalins.
Uses of Azathioprine.
Crohn’s – severe acute and maintenance of remission.
UC – maintenance of remission.
RA – unresponsive to other DMARDs.
Suppression of transplant rejection.
Metabolised product of Azathioprine.
Mercaptopurine.
Monitoring of Azathioprine.
Pre: TPMT enzyme levels.
During: weekly FBC (8 weeks) then 3 monthly.
Toxicity.
What should be given with Methotrexate to reduce the risk of toxicity?
Folic acid.
Given weekly on a different day to methotrexate.
Important risk of corticosteroid treatment (in relation to immune suppression).
May suppress an immune response to infection so that it presents late at an advanced stage.
Where is information on immunosuppressants found in the BNF?
Treatment summary: immune response.
Conditions methotrexate is used in.
Severe crohn’s – maintenance and remission.
Rheumatoid arthritis.
Methotrexate and contraception.
Effective contraception needed in men and women during treatment and for 3 months after finishing.
Pretreatment tests for methotrexate.
Pregnancy.
Liver and renal function.
Monitoring in methotrexate.
FBC, renal and liver function weekly until therapy stabilised, then every 2-3 months.
Report any signs of infection, particularly sore throat, immediately.
