Specific Cancers Flashcards
Carcinoma
Cytokeratin
GIST
C-kit/CD117 +/-, SMA +/-, CD34 POSITIVE, Dog-1 POSITIVE, vimentin POSITIVE
HSA
Factor 8 Rag/vWF +, CD31/PECAM +, VEGF +, CD34 +
Lymphangiosarcoma
LYVE-1, PROX-1 POSITIVE
Histocytic Sarcoma
CD18, lysozyme, Iba-1 POSITIVE, NEGATIVE for Cd11d
Leiomyoma/Leiomyosarcoma
SMA+, Caldesmon+, Desmin +/-, Calponin +
B cell LSA
CD79a, Pax5, CD21 POSITIVE
T cell LSA
CD3, CD18 +/-, CD8, CD4, CD5 POSITIVE
MCT
Tryptase, CD18, C-kit
Melanocytic
Melan-A +/-, rare positive in melanotic, PNL2 +/-, tyrosinase +/-, TRP-1/2 +/-, Vimentin +, S-100 +/-
Neural Astrocytic (astrocytoma, glioblastoma, oligoastrocytoma)
GFAP+ (oligo NEGATIVE), S-100 +/-, CNPase + (Astro NEGATIVE)
Plasma Cell Tumor
MUM-1/IRF4+, CD18 +/-, CD79a +/-
Neuroendocrine
Chromogranin A +, Synaptophysin +, NSE +
Rhabdomyosarcoma
Vimentin+, actin sarcomeric +, Desmin +, myoglobin +/- (late stage marker and may be negative in poorly differentiated rhabdos)
Sarcoma
Vimentin
Thyroid Tumor (follicular)
Thyroglobulin +, TTF-1 +
Cutaneous Histiocytoma/Langerhans Cell Histiocytosis
CD18/Iba-1 POSITIVE< Cd11d NEGATIVE, E-cadherin POSITIVE
Thyroid Tumor (C-cell/Medullary)
Thyroglobulin NEGATIVE, TTF-1 +, Calcitonin +, chromogranin A +, synaptophysin +, NSE +
Mesothelioma
HMW CKs +, CK5+, vimentin +/-
HCC
HepPar1 +, CK7 +
Prostatic Carcinoma
PSA +
Histiocytoma
ALWAYS POSITIVE FOR E-CADHERIN
Cholangiocellular Carcinoma
HerPar NEGATIVE, Ck7 +
Hemophagocytic HS
CD18/Iba-1 POSITIVE, CD11D NEGATIVE
