Specific Cancers

Question 1

Carcinoma

Answer 1

Cytokeratin

Question 2

GIST

Answer 2

C-kit/CD117 +/-, SMA +/-, CD34 POSITIVE, Dog-1 POSITIVE, vimentin POSITIVE

Question 3

HSA

Answer 3

Factor 8 Rag/vWF +, CD31/PECAM +, VEGF +, CD34 +

Question 4

Lymphangiosarcoma

Answer 4

LYVE-1, PROX-1 POSITIVE

Question 5

Histocytic Sarcoma

Answer 5

CD18, lysozyme, Iba-1 POSITIVE, NEGATIVE for Cd11d

Question 6

Leiomyoma/Leiomyosarcoma

Answer 6

SMA+, Caldesmon+, Desmin +/-, Calponin +

Question 7

B cell LSA

Answer 7

CD79a, Pax5, CD21 POSITIVE

Question 8

T cell LSA

Answer 8

CD3, CD18 +/-, CD8, CD4, CD5 POSITIVE

Question 9

MCT

Answer 9

Tryptase, CD18, C-kit

Question 10

Melanocytic

Answer 10

Melan-A +/-, rare positive in melanotic, PNL2 +/-, tyrosinase +/-, TRP-1/2 +/-, Vimentin +, S-100 +/-

Question 11

Neural Astrocytic (astrocytoma, glioblastoma, oligoastrocytoma)

Answer 11

GFAP+ (oligo NEGATIVE), S-100 +/-, CNPase + (Astro NEGATIVE)

Question 12

Plasma Cell Tumor

Answer 12

MUM-1/IRF4+, CD18 +/-, CD79a +/-

Question 13

Neuroendocrine

Answer 13

Chromogranin A +, Synaptophysin +, NSE +

Question 14

Rhabdomyosarcoma

Answer 14

Vimentin+, actin sarcomeric +, Desmin +, myoglobin +/- (late stage marker and may be negative in poorly differentiated rhabdos)

Question 15

Sarcoma

Answer 15

Vimentin

Question 16

Thyroid Tumor (follicular)

Answer 16

Thyroglobulin +, TTF-1 +

Question 17

Cutaneous Histiocytoma/Langerhans Cell Histiocytosis

Answer 17

CD18/Iba-1 POSITIVE< Cd11d NEGATIVE, E-cadherin POSITIVE

Question 18

Thyroid Tumor (C-cell/Medullary)

Answer 18

Thyroglobulin NEGATIVE, TTF-1 +, Calcitonin +, chromogranin A +, synaptophysin +, NSE +

Question 19

Mesothelioma

Answer 19

HMW CKs +, CK5+, vimentin +/-

Question 20

HCC

Answer 20

HepPar1 +, CK7 +

Question 21

Prostatic Carcinoma

Answer 21

PSA +

Question 22

Histiocytoma

Answer 22

ALWAYS POSITIVE FOR E-CADHERIN

Question 23

Cholangiocellular Carcinoma

Answer 23

HerPar NEGATIVE, Ck7 +

Question 24

Hemophagocytic HS

Answer 24

CD18/Iba-1 POSITIVE, CD11D NEGATIVE

Question 25

PNET

Answer 25

Synaptophysin +, NeuN +/-, neurofilament M phosphorylated +, doublecortin +

Question 26

Synovial cell sarcoma

Answer 26

Vimentin +, cytokeratin NEGATIVE, CD18 NEGATIVE

Question 27

Meningioma

Answer 27

E-cadherin +, Claudin-1 +/-, CD34 +

Question 28

Which tumors co-express vimentin and cytokeratin?

Answer 28

RCC, synovial cell carcinoma?, mesothelioma, meningioma

Question 29

CD90 expressed by?

Answer 29

Dendritic cells