Broad Groups

Question 1

Adrenal Markers

Answer 1

Melan-A (cortex), Hydroxylase (medulla), inhibin-alpha, calrethinin, chromogranin, synaptophysin, PGP 9.5

Question 2

Cancer of Unknown Origin

Answer 2

Cos AE1/AE3 (carcinomas), vimentin (sarcoma), CD18 (leukocyte), S100 (melanocytic, neural)

Question 3

Endocrine

Answer 3

Chromogranin A, Synaptophysin, PGP 9.5

Question 4

Epithelial vs Mesenchymal

Answer 4

Cytokeratin (epithelial), vimentin (mesenchymal)

Question 5

Leukocytic (Histiocytic)

Answer 5

CD45 (panleukocytic), CD18 (panleukocytic w/ histio emphasis), CD11d (splenic macrophages), E-cadherin (langerhans cells), Iba-1 (all histiocytes), CD90 (some dendritic cells and T’s)

Question 6

Lung

Answer 6

TTF-1, Napsin-A

Question 7

Melanocytic

Answer 7

Melan-A, PNL2, S100

Question 8

MCT

Answer 8

Kit (CD117), tryptase

Question 9

Neurogenic

Answer 9

S100 (neurons, glial cells, meningiothelial cells), GFAP (glial cells, ependymal cells), GNPase, Olig2

Question 10

Muscle

Answer 10

SMA (smooth muscle), Actin sarcomeric ( striated muscle), MYOD1 (rhabdomyosarcoma)

Question 11

Pancreas

Answer 11

Insulin, glucagon, somatostatin, gastrin

Question 12

Renal

Answer 12

Pax8, Napsin A

Question 13

Squamous vs ACA

Answer 13

CK5 (squamous), CK7 (ACA)

Question 14

Thyroid

Answer 14

Thyroglobulin (follicular), calcitonin (medulla, C-cells), TTF-1, Pax8, Napkin A

Question 15

Urothelial

Answer 15

Uroplakin 2 & 3

Question 16

Vascular

Answer 16

Factor 8Rag, CD31/PECAM, CD34 (all vessels), LYVE1 & PROX 1 (lymphatic vessels)