Specific Acquired Immunity

Question 1

IL-2 and IL-15

Answer 1

General activators of T cells

Question 2

IL-12 and IFN-gamma

Answer 2

Drive T helper cells to Th1 helper cell subtypes

Question 3

IL-4

Answer 3

Drives T helper cells to Th2 helper cell subtypes

Question 4

IL-10

Answer 4

Down-regulates Th1

Question 5

TGF-beta

Answer 5

Down-regulates Th1 and Th2 subtypes

Question 6

X-linked agammaglobulinemia

Answer 6

Absence of B lymphocytes

Question 7

CD40 Ligand Deficiency

Answer 7

Failure of immunoglobulin class switching

Question 8

Th1

Answer 8

Recognize antigen–>make lymphokine that attracts 1000’s of macrophages to where antigens have been recognized. Focused inflammation Can help wipe out serious infections

Question 9

Th2

Answer 9

Stimulates macrophage to become alternatively activated and help wall-off pathogens and promote healing. Very important in parasitic immunity.

Question 10

Th17

Answer 10

Focused inflammation. More powerful to Th1. Have been implicated in many serious forms of autoimmunity.

Question 11

Tfh

Answer 11

Stimulated by antigen and migrate from T cell areas of lymph nodes into B cell follicles. Help B cells get activated. IgG, IgM, IgE, IgA.

Question 12

Treg

Answer 12

Makes cytokines that suppress activation and functon of Th1, Th2, Th17 to keep immune reponse in check.

Question 13

Lymphocyte markers of T cells

Answer 13

CD3, CD4, CD8, CD23

Question 14

Lymphocyte markers of B cells

Answer 14

CD79a, CD79b, CD40

Question 15

MHC1

Answer 15

Antigens synthesized within the cell. Recognized by CD8+ killer T cells. All cells express except RBC’s

Question 16

MHC2

Answer 16

Antigens produced by phagocytosis. Recognized by CD4+ helper cells. Expressed on monocytes/macrophages, dendritic cells ,B cells, epithelial cells of thymus

Question 17

2 mechanisms that killer T cells can use to cause cell death

Answer 17

1. FAS protein-FAS ligand interaction.

2. Killing by secreting toxic agents