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Specialties Flashcards

1
Q

Repatha: generic name?

A

Evolocumab

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2
Q

Evolocumab: brand name?

A

Repatha

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3
Q

Repatha: indication(s)?

A

Hypercholesterolemia

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4
Q

Repatha: mechanism of action?

A

PCSK9 inhibitor.
PCSK9 connects to the LDL-R and prevents its recycling to the hepatocyte surface, thus decreasing LDL-R on hepatocytes. Inhibiting PCSK9 increases LDL-R amount on hepatocyte surface.

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5
Q

Repatha: partner?

A

Amgen

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6
Q

Repatha: main competition?

A

Praluent (Alirocumab), 80% of Israeli market share

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7
Q

Tepezza: generic name?

A

Teprotumumab

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8
Q

Teprotumumab: brand name?

A

Tepezza

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9
Q

Tepezza: Indication(s)?

A

Thyroid eye disease (TED)

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10
Q

Tepezza: partner?

A

Amgen

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11
Q

Tepezza: administration?

A

IV, once every 3 weeks, for a total of 8 infusions.

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12
Q

Prolia: generic name?

A

Denosumab

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13
Q

Denosumab: brand name?

A

Prolia

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14
Q

Prolia: partner?

A

Amgen

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15
Q

Prolia: Indication(s)?

A

Osteoporosis

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16
Q

Prolia: mechanism of action?

A

RANK Ligand inhibitor - decreasing osteoclast activity and survival

17
Q

Prolia: administration?

A

S/C, once every 6 months

18
Q

Prolia: main competition?

A

Aclasta (zoledronic acid)

19
Q

Evenity: generic name?

A

Romosozumab

20
Q

Romosozumab: brand name?

21
Q

Evenity: partner?

22
Q

Evenity: indication(s)?

A

Osteoporosis

23
Q

Evenity: Mechanism of action?

A

Sclerostin inhibitor (monoclonal antibody).
Dual effect - both increasing osteoblastic activity and decreasing osteoclastic activity.

24
Q

Evenity: administration?

A

S/C, once a month for 12 months.

25
Q

Trikafta: generic name(s)?

A

Elexacaftor / Tezacaftor / Ivacaftor, and Ivacaftor

26
Q

Trikafta: indication(s)?

A

CF above age 2y, with at least one F508del mutation

27
Q

Trikafta: mechanism of action?

A

Elexacaftor and Tezacaftor improve cellular processing of CFTR so more reach the cell membrane; Ivacaftor improves open channel probability (gating).

28
Q

Trikafta: administration?

A

PO, daily.
Combination at morning + Ivacaftor at evening.

29
Q

Trikafta: partner?

30
Q

Elafibrinor: Indication(s)?

A

Primary Biliary Cholangitis (PBC)

31
Q

Elafibrinor: Partner?

32
Q

Elafibrinor: administration?

33
Q

Elafibranor: mechanism of action?

A

Dual PPAR-alpha and PPAR-delta agonist

34
Q

Bylvay: generic name?

A

Odevixibat

35
Q

Odevixibat: brand name?

36
Q

Bylvay: partner?

37
Q

Bylvay: indication(s)?

A
  1. Progressive Familial Intrahepatic Cholestasis (PFIC) > 6 months of age
  2. Alagille syndrome >12 months of age
38
Q

Bylvay: administration?

A

PO, once daily

39
Q

Bylvay: mechanism of action?

A

Ileal Bile Acid Transporter (IBAT) inhibitor, decreasing bile acid reabsorption and increasing its fecal excretion

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