SPECIALIZED IMMUNITY AT EPITHELIAL BARRIERS AND IN IMMUNE PRIVILEGED TISSUES Flashcards
the skin and
mucosae form the the
barrier immune system,
technically considered a
component of the ______
immune system.
innate
function of skin/mucosal surface
These structures form
physical barriers to infection
that prevent pathogens from
entering the body through a
variety of methods.
primary lymphoid organ includes
bone marrow , thymus
secondary lymphoid organ includes
lymph nodes, tonsils, spleen peyer’s patches, appendix
____________-organs, where lymphocytes first express antigen receptors and attain phenotypic and functional maturity,
primary or central lymphoid (generative)
peripheral organs, also called ________ lymphoid organs, where lymphocyte responses to foreign antigens are initiated and develop (immune response).
secondary
what’s abundant in the gastrointestinal immune system and can participate in stimulating protective
effector T cell responses or inducing regulatory T cell responses that
suppress immunity to ingested antigens
and commensal organisms.
DCs and macrophages
what’s abundant in the intestinal mucosa
Th17 effector T cells and regulatory T cells
T/f UVB stimulate production of vitamin D.which induces expression of CCR10; IL-2 induces expression of the E selectin ligand, CLA, and other signals like CCR4, CCR8 and CCR10
True
When naive b and T cells activated by antigen in Galt, it’s exposed to the retnoic acid from DC, which induces expression of ____ on the plasma-blasts and effector T cells
CCR9 receptors and integrin a4b7
M cells located in ____ that overlie the domes of Peyers patch and other GALT structures
Follicle-asssociated (done) epithelium
T/f: M cells have thin short gyclocalyx, irregular microvilli and large fenestrations
True
