Special Selective Vulnerabilities

Question 1

what components are at risk for damage from brain contusions? why?

Answer 1

orbital and temporal regions b/c of irregularities of adjacent inner surfaces

Question 2

what components are at risk from ischemia? why?

Answer 2

neurons in CA1 of the hippocampus and Purkinje cells of the cerebellum due to their high concentration of glutamate receptors (which makes them prone to excitotoxicity)

Question 3

what components are at risk from CO intoxication? why?

Answer 3

globus pallidus and substantia nigra; due to high concentration of iron containing substances with a high affinity for CO

Question 4

what area is at high risk from methanol? chronic ethanol?

Answer 4

putamen and anterior cerebellar vermis (reasons unknown)