iPD

Question 1

what is the mean age of onset for iPD?

Answer 1

60

Question 2

what is the classic combination of clinical symptoms associated with iPD?

Answer 2

bradykinesia, bradyphrenia, shuffling gait, stooped posture, masked facies, tremors, rigidity & difficulty arising from a chair

Question 3

what is the classic pathologic change of iPD?

Answer 3

loss of the pigmented neurons from the substantia nigra

Question 4

what are Lewy bodies?

Answer 4

eosinophilic cytoplasmic inclusion of alpha-synuclein (mostly) in neurons

Question 5

what mutations are there for iPD?

Answer 5

SNCA, PARK2 (parkin) PARK7 (DJ-1) PINK1 (PTEN induced kinase), LRRK (dardarin)

Question 6

environmental risk factors for iPD?

Answer 6

MPTP (heroin outbreak), pesticides, herbicides, heavy metals and solvents

Question 7

in Dementia with Lewy Bodies, what are Lewy neurites?

Answer 7

abnormal alpha-synuclein rich neuronal processes in the gray matter

Question 8

what are the two types of pathologies of Dementia with Lewy Bodies?

Answer 8

those that have lewy bodies in the brain stem, cerebral cortex: a rostral extension of the Parkinson’s disease
and those that have neocortical Lewy bodies and concomitant ALZ pathology

Question 9

what is the usual presentation of dementia with lewy bodies?

Answer 9

visual hallucinations and REM sleep behavior disorders

Question 10

what is the diagnosis of DwLB?

Answer 10

has to be clinical because the only definitive diagnosis is from pathology which is usually done at autopsy

Question 11

in the ALZ with LB form, what is the current nomenclature?

Answer 11

mixed ALZ/Lewy Body disease