Spasticity, Opioids and NSAIDs

Question 1

Neurontin (Gabapentin)

Answer 1

Acts centrally to reduce excitability

Question 2

Lioresal (Baclofen)

Answer 2

Acts centrally to reduce excitability

Question 3

Botox (Botulinum)

Answer 3

Prevents Ach release at the NMJ and reduces excitability at the peripheral level

Question 4

Valium (Diazepam)

Answer 4

Muscle relaxer that inhibits GABA by binding to GABA-A receptors

Question 5

Flexeril (Cyclopenzaprine)

Answer 5

Muscle relaxer that decreases excitatory signals by modulating norE - has ANS affects

Question 6

Tylenol (Acetaminophen)

Answer 6

Blocks COX enzymes for pain relief, fever reducer

Question 7

Codeine

Answer 7

Opioid that binds to MOR and decreases neurotransmitter release of substance P, GABA and glutamate

Question 8

Hycodan (Hydrocodone)

Answer 8

Opioid

Question 9

Oxycontin (Oxydocone)

Answer 9

Opioid

Question 10

Aspirin (Acetylsalicyclic acid)

Answer 10

NSAID - Inhibits COX-1 and COX-2

Question 11

Voltaren (Diclofenac)

Answer 11

NSAID - Inhibits COX-1 and COX-2

Question 12

Mobic (Meloxicam)

Answer 12

NSAID - Inhibits COX-1 and COX-2

Question 13

Advil (Ibuprofen)

Answer 13

A: GI tract
M: Liver (1st pass)
D: Throughout the body
E: Urine

Question 14

Naprosyn (Naproxen)

Answer 14

NSAID

Question 15

Celebrex (Celecoxib)

Answer 15

Selective NSAID - Inhibits COX-2

Question 16

Synvisc

Answer 16

Viscosupplement

Question 17

Narcan (Naloxone)

Answer 17

Opioid antagonist - Blocks opioid receptor