Some Lipid stuff Flashcards
Apolipoprotein that mediates endocytosis of LDL
apoB-100 (the sole protein component of LDL)
Apolipoprotein that activates LPL (lipoprotein lipase)?
apoC-II, the LPL releases FFAs to be taken up and stored in adipose and muscle peripheral tissue, while glycerol is taken up by liver
Apolipoprotein that permits uptake of remnants of chylomicron by liver?
eg VLDL (IDL) etc. ApoE
Reverse cholesterol transport …
Process by which HDL carries cholesterol back to the liver
HDL and LDL are …
Lipoproteins that carry cholesterol
Components of lipoprotein complex …
Cholesterol, triglycerides, phospholipids and apolipoproteins
Lipoproteins in HDL …
apoC-II, apoE, also ApoA-I and ApoA-II
Lipoprotein that activate LCAT? And what does LCAT do?
lecithin-cholesterol acyltransferase
ApoA-I from HDL
LCAT converts cholesterol to cholesterol ester (more hyrdrophobic form) sequestered in core of lipoprotein giving it spherical shape
Hepatic triglycerides released to bloodstream as what lipoprotein complex?
TGs + apoB-100 to form VLDL
VLDL picks up what lipoproteins and from where before entering blood?
apoC-II and apoE from HDL
Can VLDL be directly converted to LDL? Can IDL?
NO! but IDL can via removal of TGs from IDL by LPL or hepatic lipase
HDL (where synthesized/3 fxns)
Sytnh de novo in liver and intestines
1) activates LCAT using apoA-I
2) transports cholesterol from periph tissues to liver and steroidogenic tissues
3) donates apoC-II and apoE to chylomicrons and VLDL
ABC-AI
ATP-binding cassette transporter A1 - enables lipoproteins (HDL) to pick up cholesterol from cells (membrane transporter protein)
Defic: Tangier’s dz
