Solubility & Permeability Flashcards
1
Q
Why is solubility and permeability important?
A
- Bioavailability (Unchanged drug upon reaching systemic circulation)
- Absorption through membranes (Hydrophillicity and lipophillicity)
- Dissolve in biological fluids (Distribution)
- Blood, Interstitial, CSF
- Side effects/toxicity
- Excretion/Metabolism
2
Q
Which functional groups are water insoluble?
A
- Alkanes, alkenes, aromatic hydrocarbons, halogenated hydrocarbons
3
Q
Which functional groups are partially water soluble?
A
- Ethers, ketones, aldehydes, esters
4
Q
Which functional groups are water soluble?
A
Alcohols, phenols, amines, carboxylic acids, sulfonic acids, amides, salts of acids/bases
5
Q
What is a dielectric constant?
A
- Measurement of a medium’s polarity
- High dielectric constant, high polarity, better solvation!
